A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors

H Wang, T Qian, Y Zhao, Y Zhuo, C Wu, T Osakada… - Science, 2023 - science.org
Neuropeptides are key signaling molecules in the endocrine and nervous systems that
regulate many critical physiological processes. Understanding the functions of …

Current and emerging methods for probing neuropeptide transmission

T Qian, H Wang, X Xia, Y Li - Current Opinion in Neurobiology, 2023 - Elsevier
Neuropeptides comprise the most diverse category of neurochemicals in the brain, playing
critical roles in a wide range of physiological and pathophysiological processes. Monitoring …

Imaging neuropeptide release at synapses with a genetically engineered reporter

K Ding, Y Han, TW Seid, C Buser, T Karigo, S Zhang… - Elife, 2019 - elifesciences.org
Research on neuropeptide function has advanced rapidly, yet there is still no spatio-
temporally resolved method to measure the release of neuropeptides in vivo. Here we …

Peptidomics for the discovery and characterization of neuropeptides and hormones

EV Romanova, JV Sweedler - Trends in Pharmacological Sciences, 2015 - cell.com
The discovery of neuropeptides as signaling molecules with paracrine or hormonal
regulatory functions has led to trailblazing advances in physiology and fostered the …

Emerging approaches for decoding neuropeptide transmission

KS Girven, L Mangieri, MR Bruchas - Trends in neurosciences, 2022 - cell.com
Neuropeptides produce robust effects on behavior across species, and recent research has
benefited from advances in high-resolution techniques to investigate peptidergic …

New techniques, applications and perspectives in neuropeptide research

K DeLaney, AR Buchberger… - Journal of …, 2018 - journals.biologists.com
Neuropeptides are one of the most diverse classes of signaling molecules and have
attracted great interest over the years owing to their roles in regulation of a wide range of …

Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators

H Wang, M Jing, Y Li - Current opinion in neurobiology, 2018 - Elsevier
Highlights•Genetically-encoded fluorescent sensors are essential for studying
neurotransmission.•Today's sensors are limited in certain aspects, especially for in vivo …

[HTML][HTML] Neuropeptide regulation of signaling and behavior in the BNST

TL Kash, KE Pleil, CA Marcinkiewcz… - Molecules and cells, 2015 - Elsevier
Recent technical developments have transformed how neuroscientists can probe brain
function. What was once thought to be difficult and perhaps impossible, stimulating a single …

G‐protein‐coupled receptor‐based sensors for imaging neurochemicals with high sensitivity and specificity

M Jing, Y Zhang, H Wang, Y Li - Journal of neurochemistry, 2019 - Wiley Online Library
Neurotransmitters and neuromodulators are key neurochemicals that mediate cell–cell
communication, maintain the body's homeostasis, and control a wide range of biological …

A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine

J Feng, C Zhang, JE Lischinsky, M Jing, J Zhou… - Neuron, 2019 - cell.com
Norepinephrine (NE) is a key biogenic monoamine neurotransmitter involved in a wide
range of physiological processes. However, its precise dynamics and regulation remain …