Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study

FLG Altamirano, X Kostoulias, D Subedi, D Korneev… - …, 2022 - thelancet.com
Background Clinical phage therapy is often delivered alongside antibiotics. However, the
phenomenon of phage-antibiotic synergy has been mostly studied in vitro. Here, we …

Antibiotics Act with vB_AbaP_AGC01 Phage against Acinetobacter baumannii in Human Heat-Inactivated Plasma Blood and Galleria mellonella Models

B Grygorcewicz, M Roszak, P Golec… - International Journal of …, 2020 - mdpi.com
Increasing multidrug resistance has led to renewed interest in phage-based therapy. A
combination of the bacteriophages and antibiotics presents a promising approach …

Combined Use of the Ab105-2φΔCI Lytic Mutant Phage and Different Antibiotics in Clinical Isolates of Multi-Resistant Acinetobacter baumannii

L Blasco, A Ambroa, M Lopez, L Fernandez-Garcia… - Microorganisms, 2019 - mdpi.com
Phage therapy is an abandoned antimicrobial therapy that has been resumed in recent
years. In this study, we mutated a lysogenic phage from Acinetobacter baumannii into a lytic …

Characterization and Testing the Efficiency of Acinetobacter baumannii Phage vB-GEC_Ab-M-G7 as an Antibacterial Agent

I Kusradze, N Karumidze, S Rigvava… - Frontiers in …, 2016 - frontiersin.org
Acinetobacter baumannii is a gram-negative, non-motile bacterium that, due to its multidrug
resistance, has become a major nosocomial pathogen. The increasing number of multidrug …

Acinetobacter baumannii Resistance: A Real Challenge for Clinicians

R Vázquez-López, SG Solano-Gálvez… - Antibiotics, 2020 - mdpi.com
Acinetobacter baumannii (named in honor of the American bacteriologists Paul and Linda
Baumann) is a Gram-negative, multidrug-resistant (MDR) pathogen that causes nosocomial …

Personalized therapeutic cocktail of wild environmental phages rescues mice from Acinetobacter baumannii wound infections

JM Regeimbal, AC Jacobs, BW Corey… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Multidrug-resistant bacterial pathogens are an increasing threat to public health, and lytic
bacteriophages have reemerged as a potential therapeutic option. In this work, we isolated …

Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive …

X Tan, H Chen, M Zhang, Y Zhao, Y Jiang… - Frontiers in cellular …, 2021 - frontiersin.org
Overuse of antibiotics in clinical medicine has contributed to the global spread of multidrug-
resistant bacterial pathogens, including Acinetobacter baumannii. We present a case of an …

[HTML][HTML] Phage Abp1 rescues human cells and mice from infection by pan-drug resistant Acinetobacter baumannii

S Yin, G Huang, Y Zhang, B Jiang, Z Yang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: As an “ESKAPE” pathogen, Acinetobacter baumannii is one of the
leading causes of drug-resistant infections in humans. Phage therapy may be a useful …

[HTML][HTML] Developing new therapeutic approaches for treating infections caused by multi-drug resistant Acinetobacter baumannii: Acinetobacter baumannii therapeutics

P Gallagher, S Baker - Journal of Infection, 2020 - Elsevier
Antimicrobial resistance (AMR) represents a major challenge to global health. This problem
is most apparent in healthcare facilities, with a comparatively small number of pathogens …

Comparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy

M Liu, A Hernandez-Morales, J Clark, T Le… - Nature …, 2022 - nature.com
Abstract In 2016, a 68-year-old patient with a disseminated multidrug-resistant Acinetobacter
baumannii infection was successfully treated using lytic bacteriophages. Here we report the …