High expression of ubiquitin-specific protease 10 (USP10) promote the proliferation of
hepatocellular carcinoma (HCC), thus the development of USP10 inhibitors holds promise …

Background Ubiquitin-specific protease 7 (USP7) is a de-ubiquitin enzyme that plays an
essential role in multiple cancers and becomes a target for treatment. However, the role of …

The ubiquitin-specific protease 8 (USP8) is a prototypic multidomain deubiquitinating
enzyme with pleiotropic functions. We investigated the role of USP8 in hepatocellular …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide.
Ubiquitin‑specific protease 12 (USP12) is specifically upregulated in the tumor tissues of …

Abstract Ubiquitin-specific protease 22 (USP22) plays a prominent role in tumor
development, invasion, metastasis and immune reprogramming, which has been proposed …

Hippo pathway plays a crucial role in the progression of hepatocellular carcinoma (HCC),
and yes-associated protein (YAP) is one of the major factors of the Hippo pathway. However …

Abstract Ubiquitin‐specific peptidase 13 (USP13) has been reported to be involved in the
tumorigenesis of several tumors, but its function in tumors is still controversial. In this study …

USP15 is a member of ubiquitin-specific proteases (USPs, the largest subfamily of
deubiquitinases) and functions as a stabilize factor of target proteins in reversible …

Hepatocellular carcinoma (HCC) is the most frequently diagnosed primary liver cancer with
a high mortality rate and imposes a huge burden on patients and society. Recently, ubiquitin …

Despite of advances in treatment options, hepatocellular carcinoma (HCC) remains nearly
incurable and has been recognized as the third leading cause of cancer-related deaths …