Programmable cell-free transcriptional switches for antibody detection
We report here the development of a cell-free in vitro transcription system for the detection of
specific target antibodies. The approach is based on the use of programmable antigen …
specific target antibodies. The approach is based on the use of programmable antigen …
Synthetic antigen-conjugated dna systems for antibody detection and characterization
Antibodies are among the most relevant biomolecular targets for diagnostic and clinical
applications. In this Perspective, we provide a critical overview of recent research efforts …
applications. In this Perspective, we provide a critical overview of recent research efforts …
Antibody activation using DNA‐based logic gates
BMG Janssen, M van Rosmalen… - Angewandte …, 2015 - Wiley Online Library
Oligonucleotide‐based molecular circuits offer the exciting possibility to introduce
autonomous signal processing in biomedicine, synthetic biology, and molecular diagnostics …
autonomous signal processing in biomedicine, synthetic biology, and molecular diagnostics …
Plug-and-play protein biosensors using aptamer-regulated in vitro transcription
Molecular biosensors that accurately measure protein concentrations without external
equipment are critical for solving numerous problems in diagnostics and therapeutics …
equipment are critical for solving numerous problems in diagnostics and therapeutics …
Engineering biosensors with dual programmable dynamic ranges
Although extensively used in all fields of chemistry, molecular recognition still suffers from a
significant limitation: host–guest binding displays a fixed, hyperbolic dose–response curve …
significant limitation: host–guest binding displays a fixed, hyperbolic dose–response curve …
Programmable, multiplexed DNA circuits supporting clinically relevant, electrochemical antibody detection
Current health emergencies have highlighted the need to have rapid, sensitive, and
convenient platforms for the detection of specific antibodies. In response, we report here the …
convenient platforms for the detection of specific antibodies. In response, we report here the …
Programmable nucleic acid nanoswitches for the rapid, single-step detection of antibodies in bodily fluids
A Porchetta, R Ippodrino, B Marini… - Journal of the …, 2018 - ACS Publications
Antibody detection plays a pivotal role in the diagnosis of pathogens and monitoring the
success of vaccine immunization. However, current serology techniques require multiple …
success of vaccine immunization. However, current serology techniques require multiple …
A logical molecular circuit for programmable and autonomous regulation of protein activity using DNA aptamer–protein interactions
D Han, Z Zhu, C Wu, L Peng, L Zhou… - Journal of the …, 2012 - ACS Publications
Researchers increasingly envision an important role for artificial biochemical circuits in
biological engineering, much like electrical circuits in electrical engineering. Similar to …
biological engineering, much like electrical circuits in electrical engineering. Similar to …
Using antibodies to control DNA-templated chemical reactions
L Baranda Pellejero, M Mahdifar, G Ercolani… - Nature …, 2020 - nature.com
DNA-templated synthesis takes advantage of the programmability of DNA-DNA interactions
to accelerate chemical reactions under diluted conditions upon sequence-specific …
to accelerate chemical reactions under diluted conditions upon sequence-specific …
[PDF][PDF] In vitro selection of structure‐switching signaling aptamers
Signaling aptamers are aptamer probes that couple target binding to fluorescent-signal
generation. These molecular sensors have potential applications in biosensing, proteomics …
generation. These molecular sensors have potential applications in biosensing, proteomics …