[HTML][HTML] Autism spectrum disorder: focus on glutamatergic neurotransmission

M Montanari, G Martella, P Bonsi… - International Journal of …, 2022 - mdpi.com
Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Glutamate mediated signaling in the pathophysiology of autism spectrum disorders

PR Choudhury, S Lahiri, U Rajamma - Pharmacology Biochemistry and …, 2012 - Elsevier
Autism spectrum disorder (ASD) is a childhood neurodevelopmental disorder. During fetal
and neonatal brain development, the cues for neurodevelopment are regulated in a well …

[HTML][HTML] Genetics of glutamate and its receptors in autism spectrum disorder

S Nisar, AA Bhat, T Masoodi, S Hashem, S Akhtar… - Molecular …, 2022 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …

The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment

DC Rojas - Journal of neural transmission, 2014 - Springer
Glutamate is the major excitatory neurotransmitter in the brain and may be a key
neurotransmitter involved in autism. Literature pertaining to glutamate and autism or related …

[HTML][HTML] Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models

J Horder, MM Petrinovic, MA Mendez, A Bruns… - Translational …, 2018 - nature.com
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental syndrome with a high
human and economic burden. The pathophysiology of ASD is largely unclear, thus …

[HTML][HTML] Reduced subcortical glutamate/glutamine in adults with autism spectrum disorders: a [1H] MRS study

J Horder, T Lavender, MA Mendez, R O'gorman… - Translational …, 2013 - nature.com
Dysfunctional glutamatergic neurotransmission has been implicated in autism spectrum
disorder (ASD). However, relatively few studies have directly measured brain glutamate in …

Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders

GC Carlson - Pharmacology Biochemistry and Behavior, 2012 - Elsevier
There is strong evidence that metabotropic and ionotropic glutamate receptors are affected
in autism spectrum disorders (ASD), but there are few candidate genes indicating …

[HTML][HTML] Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

[HTML][HTML] Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance …

L Tebartz van Elst, S Maier, T Fangmeier… - Molecular …, 2014 - nature.com
Over the last few years, awareness of autism spectrum disorder (ASD) in adults has
increased. The precise etiology of ASD is still unresolved. Animal research, genetic and …

Elevated plasma levels of glutamate in children with autism spectrum disorders

J Cai, L Ding, JS Zhang, J Xue, LZ Wang - Neuroreport, 2016 - journals.lww.com
Excitatory neurotransmitter signaling through glutamate receptors modulates cognitive
functions such as memory and learning, which are usually impaired in autism spectrum …