Detection of antibodies is essential for the diagnosis of many diseases including infections,
allergies, and autoimmune diseases. Current heterogeneous immunoassays require …

Our objective is to produce a protein biosensor (or molecular switch) that is specifically
activated in solution by a monoclonal antibody. Many effector-dependent enzymes have …

Protein switches have potential applications as biosensors and selective protein
therapeutics. Protein switches built by fusion of proteins with the prerequisite input and …

All biosensing platforms rest on two pillars: specific biochemical recognition of a particular
analyte and transduction of that recognition into a readily detectable signal. Most existing …

Detection of antibodies is essential for the diagnosis of many disease states, including
infectious diseases, autoimmune diseases and allergies. Most current antibody detection …

Several important drug targets, eg, ion channels and G protein–coupled receptors, are
extremely difficult to approach with current antibody technologies. To address these targets …

Engineering antibodies to improve target specificity, reduce detection limits, or introduce
novel functionality is an important research area for biosensor development. While various …

The ability to conditionally direct antibodies is a potentially powerful application for Synthetic
Biology in Medicine. Here we show that control of antibody binding through site-specific …

Numerous peptide ligands including protease recognition sequences, peptides mediating
protein–protein interactions, peptide epitopes of antibodies and mimotopes are available …

Protein biosensors play increasingly important roles in cell and neurobiology and have the
potential to revolutionise the way clinical and industrial analytics are performed. The gradual …