The mammary gland (MG) is an exocrine gland present in female mammals responsible for
the production and secretion of milk during the process of lactation. It is mainly composed by …

The mammary gland is unique in its requirement to develop in close association with a
depot of adipose tissue that is commonly referred to as the mammary fat pad. As discussed …

Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose
tissue is generally linked to excessive body fat, and it is well known that the female breast is …

Breast cancer is the female malignant neoplasia with the highest incidence in the
industrialized world. Despite many undeniable therapeutic successes obtained, breast …

Mammary adipose tissue (AT) is necessary for breast epithelium. However, in breast cancer
(BC), cell-cell interactions are deregulated as the tumor chronically modifies AT …

Adipose tissue is the primary source of many pro-inflammatory cytokines in obesity.
Macrophage numbers and pro-inflammatory gene expression are positively associated with …

Obesity and excess accumulation of adipose tissue are known risk factors for several types
of cancer, including breast cancer. With the incidence of obesity constantly rising worldwide …

Simple Summary Breast cancer is currently one of the most common types of cancer and the
number one cause of cancer-related deaths in women worldwide. Despite significant …

Simple Summary Breast cancer is the second most common cancer in women worldwide.
The risk of developing breast cancer depends on various mechanisms, such as age …

Adipocytes account for the largest proportion among the cells that comprise breast tissue;
therefore, they are considered to be a critical cell type in the tumor microenvironment of …