A broad set of potential bioactive conjugate compounds has been semi-synthesized through
solution-and solid-phase organic procedures, coupling two natural pentacyclic triterpene …

Triterpenoids are compounds extensively distributed in numerous plants used in traditional
medicine. Olive oil and specially pomace olive oil are important sources of pentacyclic …

Starting from solid wastes from two‐phase olive‐oil extraction, the pentacyclic triterpenes
oleanolic acid and maslinic acid were isolated. These natural compounds were transformed …

Olive oil phenols (OOPs) are associated with the prevention of many human cancers. Some
of these have been shown to inhibit cell proliferation and induce apoptosis. However, no …

2, 3-Seco-dioic acids derived from four different triterpene skeletons were prepared and
evaluated for their anti-HIV-1 protease activity. Two A-seco derivatives showed potent …

Oleanolic acid derivatives with different lengths of 3-0-acidic acyl chains were synthesized
and evaluated for their inhibitory activity against HIV-1 protease. The lengths of the acidic …

We have previously reported the anticarcinogenic effects of an olive fruit extract composed
of pentacyclic triterpenes, the main components of which are maslinic acid (73· 25%) and …

Maslinic acid (MA), a pentacyclic triterpenoid obtained from olives that is characterized by its
antiproliferative activity in tumor cells, has become a promising molecule that could be …

Phenolic secoiridoids from olive, including oleocanthal, oleuropein and related derivatives,
are bioactive natural products with documented anticancer activities, that have mainly been …

A set of PEGylated derivatives of oleanolic and maslinic acids has been semi-synthesised,
attaching ethylene glycol, diethylene glycol, triethylene glycol or tetraethylene glycol to the C …