Specificity of 3D MSC spheroids microenvironment: impact on MSC behavior and properties
A Jauković, D Abadjieva, D Trivanović… - Stem cell reviews and …, 2020 - Springer
Mesenchymal stem cells (MSC) have been considered the promising candidates for the
regenerative and personalized medicine due to their self-renewal potential, multilineage …
regenerative and personalized medicine due to their self-renewal potential, multilineage …
[HTML][HTML] Increased mesenchymal stem cell functionalization in three-dimensional manufacturing settings for enhanced therapeutic applications
D Kouroupis, D Correa - Frontiers in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of
heterogeneous cell populations, exhibiting variable stemness potential and supportive …
heterogeneous cell populations, exhibiting variable stemness potential and supportive …
Three-dimensional spheroid culture of human mesenchymal stem cells: offering therapeutic advantages and in vitro glimpses of the in vivo state
BL Yen, CC Hsieh, PJ Hsu, CC Chang… - Stem cells …, 2023 - academic.oup.com
As invaluable as the standard 2-dimensional (2D) monolayer in vitro cell culture system has
been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are …
been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are …
[HTML][HTML] Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies
Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …
Spheroid culture of mesenchymal stem cells
Z Cesarz, K Tamama - Stem cells international, 2016 - Wiley Online Library
Compared with traditional 2D adherent cell culture, 3D spheroidal cell aggregates, or
spheroids, are regarded as more physiological, and this technique has been exploited in the …
spheroids, are regarded as more physiological, and this technique has been exploited in the …
Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential
PR Baraniak, TC McDevitt - Cell and tissue research, 2012 - Springer
While traditional cell culture methods have relied on growing cells as monolayers, three-
dimensional (3D) culture systems can provide a convenient in vitro model for the study of …
dimensional (3D) culture systems can provide a convenient in vitro model for the study of …
[HTML][HTML] Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …
Engineering spheroids potentiating cell-cell and cell-ECM interactions by self-assembly of stem cell microlayer
Numerous methods have been reported for the fabrication of 3D multi-cellular spheroids and
their use in stem cell culture. Current methods typically relying on the self-assembly of …
their use in stem cell culture. Current methods typically relying on the self-assembly of …
[HTML][HTML] Changes in the transcriptome profiles of human amnion-derived mesenchymal stromal/stem cells induced by three-dimensional culture: a potential priming …
A Gallo, N Cuscino, F Contino, M Bulati… - International Journal of …, 2022 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic
tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these …
tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these …
[HTML][HTML] 3D cell sheet structure augments mesenchymal stem cell cytokine production
Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during
tissue regeneration. An increasing body of evidence suggests that this paracrine function is …
tissue regeneration. An increasing body of evidence suggests that this paracrine function is …