Mesenchymal stem cells (MSC) have been considered the promising candidates for the
regenerative and personalized medicine due to their self-renewal potential, multilineage …

Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of
heterogeneous cell populations, exhibiting variable stemness potential and supportive …

As invaluable as the standard 2-dimensional (2D) monolayer in vitro cell culture system has
been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are …

Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …

Compared with traditional 2D adherent cell culture, 3D spheroidal cell aggregates, or
spheroids, are regarded as more physiological, and this technique has been exploited in the …

While traditional cell culture methods have relied on growing cells as monolayers, three-
dimensional (3D) culture systems can provide a convenient in vitro model for the study of …

Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

Numerous methods have been reported for the fabrication of 3D multi-cellular spheroids and
their use in stem cell culture. Current methods typically relying on the self-assembly of …

Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic
tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these …

Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during
tissue regeneration. An increasing body of evidence suggests that this paracrine function is …