DNMT3a expression pattern and its prognostic value in lung adenocarcinoma
RE Husni, A Shiba-Ishii, S Iiyama, T Shiozawa, Y Kim… - Lung Cancer, 2016 - Elsevier
Objectives DNA methyltransferases (DNMTs) are an important part of the methylation
pathway that is highly correlated with the pathophysiology of cancers. Several studies have …
pathway that is highly correlated with the pathophysiology of cancers. Several studies have …
Alteration of DNA methyltransferases contributes to 5′ CpG methylation and poor prognosis in lung cancer
RK Lin, HS Hsu, JW Chang, CY Chen, JT Chen… - Lung cancer, 2007 - Elsevier
Overexpression of DNA methyltransferases DNMT1, DNMT3a and DNMT3b has been
reported in various cancers. However, physical binding of DNA methyltransferase (DNMT) to …
reported in various cancers. However, physical binding of DNA methyltransferase (DNMT) to …
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer
YM Kwon, JH Park, H Kim, YM Shim, J Kim… - Journal of cancer …, 2007 - Springer
Abstract Purpose DNA methyltransferase 1 (DNMT1) is known to play an important role in
the development of cancers. However, the underlying mechanisms responsible for the …
the development of cancers. However, the underlying mechanisms responsible for the …
Elevated mRNA levels of DNA methyltransferase‐1 as an independent prognostic factor in primary nonsmall cell lung cancer
H Kim, YM Kwon, JS Kim, J Han… - … Journal of the …, 2006 - Wiley Online Library
BACKGROUND. Despite many reports about the involvement of DNA methyltransferases
(DNMTs) in human cancers, including nonsmall cell lung cancer (NSCLC), the …
(DNMTs) in human cancers, including nonsmall cell lung cancer (NSCLC), the …
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer
J Yang, X Wei, Q Wu, Z Xu, D Gu… - Molecular …, 2011 - spandidos-publications.com
Abstract DNA methyltransferase (DNMT) 1, DNMT3A and DNMT3B, which affect promoter
CpG methylation status, play a significant role in cancer development. Little is known …
CpG methylation status, play a significant role in cancer development. Little is known …
Expression of DNA methyltransferase (DNMT) 1, 3a and 3b proteins in human hepatocellular carcinoma
T Miyake, K Endo, S Honjo, Y Hirooka… - Yonago Acta …, 2010 - repository.lib.tottori-u.ac.jp
Alteration of aberrant DNA methylation is one of the most consistent epigenetic changes
found in human cancers. DNA methylation is catalyzed by DNA methyltransferase (DNMT) …
found in human cancers. DNA methylation is catalyzed by DNA methyltransferase (DNMT) …
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer
J Xing, DJ Stewart, J Gu, C Lu, MR Spitz… - British journal of cancer, 2008 - nature.com
The abnormality of DNA methylation is involved in tumour progression, and thus has a
modulating effect on clinical outcome of cancer patients. In this study, we measured the …
modulating effect on clinical outcome of cancer patients. In this study, we measured the …
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value
D Vallböhmer, J Brabender, D Yang, PM Schneider… - Clinical lung cancer, 2006 - Elsevier
Background A significant association between aberrant methylation in regulatory regions of
tumor suppressor genes and clinical outcome in various different cancer types has been …
tumor suppressor genes and clinical outcome in various different cancer types has been …
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer
B Liu, J Song, J Luan, X Sun, J Bai… - Experimental …, 2016 - journals.sagepub.com
DNA methylation is an epigenetic DNA modification catalyzed by DNA methyltransferase 1
(DNMT1). The purpose of this study was to investigate DNMT1 gene and protein expression …
(DNMT1). The purpose of this study was to investigate DNMT1 gene and protein expression …
Deregulation of p53 and RB transcriptional control leads to overexpression of DNA methyltransferases in lung cancer
YA Tang, YT Tsai, RK Lin, HS Hsu, CY Chen… - Journal of Cancer …, 2014 - Elsevier
Background Overexpression of DNA 5'-cytosine-methyltransferases (DNMTs), which silence
genes including tumor suppressor genes, is involved in many cancers. However, the …
genes including tumor suppressor genes, is involved in many cancers. However, the …