Balance between metabolic and reproductive processes is important for survival, particularly
in mammals that gestate their young. How the nervous system coordinates this balance is an …

Estrogen signaling in the central nervous system promotes weight loss by increasing
thermogenesis and physical activity in the ventromedial hypothalamus (VMH), but the …

Despite notable genetic influences, obesity mainly results from the overconsumption of food,
which arises from the interplay of physiological, cognitive and environmental factors. In …

Oestrogen receptor alpha (ERα) signalling in the ventromedial hypothalamus (VMH)
contributes to energy homeostasis by modulating physical activity and thermogenesis …

Vulnerability to Alzheimer's disease (AD) is increased by several risk factors, including
midlife obesity, female sex, and the depletion of estrogens in women as a consequence of …

Obesity is a chronic disease with increasing prevalence worldwide. Obesity leads to an
increased risk of heart disease, stroke, and diabetes, as well as endocrine alterations …

Estrogens have preventative effects on weight gain and associated comorbidities, but the
tissue-specific targets remain unknown. Here, Xu et al.(2011) demonstrate that ablation of …

The tuberal nucleus (TN) is a surprisingly understudied brain region. We found that
somatostatin (SST) neurons in the TN, which is known to exhibit pathological or cytological …

Metabolic syndrome encompasses a spectrum of conditions that increases the risk for
cardiovascular and metabolic diseases. It is widely accepted that the sex hormone estrogen …

Puberty is a high-risk period for the development of dysregulated eating, including binge
eating. While risk for binge eating in animals and humans increases in both males and …