The interactions between cellular RNAs in MDA-MB-231 triple negative breast cancer cells
and a panel of small molecules appended with a diazirine cross-linking moiety and an …

Conspectus The function of cellular RNA is modulated by a host of post-transcriptional
chemical modifications installed by dedicated RNA-modifying enzymes. RNA modifications …

RNA is challenging to target with bioactive small molecules, particularly those of low
molecular weight that bind with sufficient affinity and specificity. In this report, we developed …

Epitranscriptomic RNA modifications can regulate mRNA function; however, there is a major
gap in our understanding of the biochemical mechanisms mediating their effects. Here, we …

A small molecule (1) with overlapping affinity for two microRNA (miRNA) precursors was
used to inform design of a dimeric compound (2) selective for one of the miRNAs. In …

Epitranscriptomic RNA modifications can regulate RNA activity; however, there remains a
major gap in our understanding of the RNA chemistry present in biological systems. Here we …

RNA offers nearly unlimited potential as a target for small molecule chemical probes and
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …

Methods to identify RNAs bound by small molecules in cells are sparse. Herein, an advance
to identify the direct RNA targets of small molecules in cells is described. The approach …

The biology of healthy and disease-affected cells is often mediated by RNA structures,
desirable targets for small molecule chemical probes and lead medicines. Although …

Covalent adduct formation between small molecules and DNA has been an effective
therapeutic strategy for cancer.[1] However, analogous approaches for disease-associated …