Epigenetic modifications (eg DNA methylation) in NAFLD and their contribution to disease
progression and extrahepatic complications are poorly explored. Here, we use an integrated …

Introduction Primary hyperoxaluria (PH) is a family of three rare genetic disorders of hepatic
glyoxylate metabolism that lead to overproduction and increased renal excretion of oxalate …

Abstract Primary hyperoxaluria type 1 (PH1), an inherited rare disease of glyoxylate
metabolism, arises from mutations in the enzyme alanine-glyoxylate aminotransferase. The …

Primary hyperoxalurias (PHs) are autosomal recessive disorders caused by the
overproduction of oxalate leading to calcium oxalate precipitation in the kidney and …

AGXT1 encodes alanine: glyoxylate aminotransferase 1 (AGT1), a liver peroxisomal
pyridoxal 5′-phosphate dependent-enzyme whose deficit causes Primary Hyperoxaluria …

Primary Hyperoxaluria Type 1 (PH1) is a rare autosomal recessive kidney stone disease
caused by deficiency of the peroxisomal enzyme alanine: glyoxylate aminotransferase …

Background Non-alcoholic fatty liver disease (NAFLD) is associated with a high risk for liver
cirrhosis and cancer. Recent studies demonstrate that NAFLD significantly impacts on the …

Background Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease
worldwide. However, its molecular pathogenesis is incompletely characterized and clinical …

PURPOSE: We define the major pathways of hepatic oxalate synthesis in humans, examine
the association with other metabolic pathways and identify ways that oxalate synthesis may …

Primary hyperoxaluria type 1 (PH1) is caused by a deficiency of the liver peroxisomal
enzyme alanine: glyoxylate-aminotransferase (AGT), which catalyzes the conversion of …