Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of hot melt extrusion

J Han, M Tang, Y Yang, W Sun, Z Yue, Y Zhang… - International Journal of …, 2023 - Elsevier
Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …

Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method

ALJ Khater, SH Almurisi, S Mahmood… - International Journal of …, 2023 - Elsevier
Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …

A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation

A Alzahrani, D Nyavanandi, P Mandati… - International Journal of …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …

[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Considerations in the formulation of amorphous solid dispersions by hot melt extrusion

S Dhoppalapudi - GSC Biological and Pharmaceutical …, 2022 - gsconlinepress.com
Hot melt extrusion is one of the most popular techniques for the manufacturing of amorphous
solid dispersions (ASDs). Over few decades, it has transitioned from lab scale to commercial …

[HTML][HTML] A review of various manufacturing approaches for developing amorphous solid dispersions

KK Konda, S Dhoppalapudi - Journal of Drug Delivery and …, 2022 - jddtonline.info
In recent years amorphous solid dispersions (ASD) has gained a tremendous response for
improving the solubility of poorly water-soluble drug substances. Despite the stability …

Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and Spray-Drying─Comparison of In Vitro and In Vivo Performance

E Trenkenschuh, SM Blattner, D Hirsh… - Molecular …, 2024 - ACS Publications
Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable
from an economic and ecological perspective but also limited to thermostable active …

The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform

Y Tian, E Jacobs, DS Jones, CP McCoy, H Wu… - International journal of …, 2020 - Elsevier
Amorphous solid dispersion (ASD) is a formulation strategy extensively used to enhance the
bioavailability of poorly water soluble drugs. Despite this, they are limited by various factors …

Downstream processing of amorphous solid dispersions into tablets

P Parupathi, S Dhoppalapudi - GSC Biological and …, 2023 - gsconlinepress.com
Amorphous solid dispersions have gained tremendous attention as a commercially viable
solubility enhancement technique for poorly water-soluble drugs. However, poor drug …

Hot melt extrusion: A single-step continuous manufacturing process for developing amorphous solid dispersions of poorly soluble drug substances

S Dhoppalapudi, P Parupathi - GSC Advanced Research and …, 2022 - gsconlinepress.com
In today's world with increasing patient population, the demand for pharmaceutical
medications is increasing enormously. However, poor solubility of drug substances and …