Dose-response studies on the effects of α-, β-, and γ-hexachlorocyclohexane on putative preneoplastic foci, monooxygenases, and growth in rat liver
C Schröter, W Parzefall, H Schröter… - Cancer research, 1987 - AACR
Abstract α-, β-, and γ-hexachlorocyclohexane (α-, β-, γ-HCH) isomers are widespread
environmental pollutants; α-HCH can cause liver tumors in rats and mice. In the present …
environmental pollutants; α-HCH can cause liver tumors in rats and mice. In the present …
Failure to discriminate initiation from promotion of liver tumors in a long-term study with the phenobarbital-type inducer α-hexachlorocyclohexane and the role of …
R Schulte-Hermann, W Parzefall - Cancer Research, 1981 - AACR
Abstract α-Hexachlorocyclohexane (α-HCH) was administered po to female Wistar rats for
periods of up to 33 months; doses were 20 mg/kg/day, 200 mg/kg every second week, or …
periods of up to 33 months; doses were 20 mg/kg/day, 200 mg/kg every second week, or …
Reversibility and Irreversibility of Liver Tumors in Mice Induced by the α Isomer of 1,2,3,4,5,6-Hexachlorocyclohexane
N Ito, M Hananouchi, S Sugihara, T Shirai, H Tsuda… - Cancer Research, 1976 - AACR
The characteristics of liver tumors in mice induced by the a isomer of 1, 2, 3, 4, 5, 6-
hexachlorocyclohexane (α-BHC), were studied with emphasis on their reversibility or …
hexachlorocyclohexane (α-BHC), were studied with emphasis on their reversibility or …
In vivo and in vitro binding of α-and γ-hexachlorocyclohexane to mouse liver macromolecules
F Iverson, JJ Ryan, R Lizotte, SL Hierlihy - Toxicology letters, 1984 - Elsevier
Abstract α-Hexachlorocyclohexane (α-HCH) but not γ-HCH, produces a strong neoplastic
response in HPB strain mouse liver. In vivo and in vitro binding studies with 14 C-labelled …
response in HPB strain mouse liver. In vivo and in vitro binding studies with 14 C-labelled …
Effect of hexachlorocyclohexane on diethylnitrosamine-induced hepatocarcinogenesis in rat and its failure to promote skin tumors on dimethylbenz [a] anthracene …
KM Munir, KVK Rao, SV Bhide - Carcinogenesis, 1984 - academic.oup.com
The promoting action of hexachlorocyclohexane (HCH) was evaluated in female Wistar rats
by counting the γ-glutamyl-transpeptidase-positive foci which appeared in the liver after …
by counting the γ-glutamyl-transpeptidase-positive foci which appeared in the liver after …
Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase …
K Imaida, C Uneyama, H Ogasawara, S Hayashi… - Cancer research, 1992 - AACR
Species and organ specificity of 6-nitrochrysene (6-NC)-induced carcinogenicity and the
potential correlation with aryl hydrocarbon hydroxylase (AHH) induction in the target organs …
potential correlation with aryl hydrocarbon hydroxylase (AHH) induction in the target organs …
Rat liver foci and in vitro assays to detect initiating and promoting effects of chlorinated ethanes and ethylenes.
HA Milman, DL Story, ES Riccio, A Sivak… - Annals of the New …, 1988 - europepmc.org
Nine chlorinated aliphatics (CAs) were examined in a rat liver foci assay for tumor initiating
and promoting activities. In this model, young adult male Osborne Mendel rats were first …
and promoting activities. In this model, young adult male Osborne Mendel rats were first …
An approach to the determination of the relative potencies of chemical agents during the stages of initiation and promotion in multistage hepatocarcinogenesis in the …
HC Pitot, HA Campbell - Environmental Health Perspectives, 1987 - ehp.niehs.nih.gov
The potency of carcinogenic agents in eliciting neoplastic lesions has long been a concern
of investigators in the field of oncology. This paper describes a method, based on …
of investigators in the field of oncology. This paper describes a method, based on …
The relevance of covalent binding to mouse liver DNA to the carcinogenic action of hexachlorocyclohexane isomers
P Sagelsdorff, WK Lutz, C Schlatter - Carcinogenesis, 1983 - academic.oup.com
Abstract [3 H] Hexachlorocyclohexane (HCH) was synthesized by chlorination of [3 H]
benzene prepared by catalytic tritiation of benzene with tritiated water. The isomers of HCH …
benzene prepared by catalytic tritiation of benzene with tritiated water. The isomers of HCH …
Pharmacokinetic factors and their implication in the induction of mouse liver tumors by halogenated hydrocarbons
HM Bolt - Mouse Liver Tumors: Relevance to Human Cancer …, 1987 - Springer
The presently available data on pharmacokinetics of halogenated solvents which produce
hepatic tumors in B6C3F1 mice, but not in rats, are reviewed. Such compounds are …
hepatic tumors in B6C3F1 mice, but not in rats, are reviewed. Such compounds are …