Familial colorectal cancer (CRC) accounts for 10% to 20% of all cases of CRC. Two major
autosomal dominant forms of heritable CRC are familial adenomatous polyposis (FAP) and …

Colon cancer, the third leading cause of mortality from cancer in the United States, afflicts
about 150,000 patients annually. More than 10% of these patients exhibit familial clustering …

Colorectal cancer is common in the Western world;~ 5% of individuals diagnosed with
colorectal cancer have an identifiable inherited genetic predisposition to this malignancy …

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …

COLORECTAL CANCER IS a relatively common dis-ease of Western populations, with a
typical onset at approximately 70 years. The epidemiology of the disease suggests that …

Colorectal cancer is the most common gastrointestinal malignancy and the second leading
cause of cancer death in both men and women in the United States. Most colorectal cancer …

The majority of colorectal cancer (CRC) cases are sporadic, with hereditary factors
contributing to approximately 35% of CRC cases. Less than 5% of CRC is associated with a …

The clearest examples of familial risk and colorectal cancer are the syndromes of familial
adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) …

Hereditary forms of colorectal cancer, as is the case with virtually all forms of hereditary
cancer, show extensive phenotypic and genotypic heterogeneity, a phenomenon discussed …

Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited
syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated …