Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine
combination therapy (triple therapy) in addition to standard care in patients with severe …

Background Sepsis and septic shock are medical emergencies resulting in significant
morbidity and mortality. Intravenous (IV) vitamin C, thiamine, and hydrocortisone have …

Background Whether hydrocortisone, vitamin C, and thiamine treatment can reduce the
mortality of patients with sepsis is controversial. Research Question To evaluate the efficacy …

Background Sepsis remains a leading cause of death worldwide despite advances in
management strategies. Preclinical and observational studies have found mortality benefit …

Background Sepsis accounts for 30% to 50% of all in-hospital deaths in the United States.
Other than antibiotics and source control, management strategies are largely supportive with …

Background: Combination of vitamin C, hydrocortisone and thiamine have recently been
used in sepsis but data of efficacy are conflicting and no data are available from developing …

Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective
than hydrocortisone alone in expediting resolution of septic shock. Objective To determine …

Importance Sepsis is a common syndrome with substantial morbidity and mortality. A
combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential …

Purpose To evaluate the effects of early combination therapy with intravenous vitamin C and
thiamine on recovery from organ failure in patients with septic shock. Methods The ascorbic …