Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
capable of degrading numerous extracellular matrix (ECM) components thus participating in …

A major hallmark of malignant disease is the capacity of cancer cells to cross tissue
boundaries and spread to distant sites throughout the body. Extracellular matrix-degrading …

Matrix metalloproteinases (MMPs) are the group of enzymes that belong to the family of zinc
dependent endopeptidases. These proteases degrade collagen and other important …

Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly
influenced by the surrounding microenvironment of the tumor. Therefore, the ability to …

Matrix metalloproteinases (MMPs) are a family of extracellular matrix degrading proteinases.
Owing to their matrix-degrading abilities and high expression in advanced tumors, MMPs …

The increasing diversity in both substrates and functions of matrix metalloproteinases
(MMPs) makes these enzymes central regulators in the complex tumor ecosystem …

The family of human matrix metalloproteinases (MMPs) comprises several tightly regulated
classes of proteases. These enzymes and their specific inhibitors play important roles in …

Introduction• MMP‐3• MMP‐8• MMP‐9• MMP‐12• MMP‐19• MMP‐26• Conclusions The
original notion that matrix metalloproteinases (MMPs) act as tumour and metastasis …

Matrix metalloproteinases have long been associated with cancer. Clinical trials of small
molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a …