Development of penipanoid C-inspired 2-benzoyl-1-methyl-2, 3-dihydroquinazolin-4 (1H)-one derivatives as potential EGFR inhibitors: Synthesis, anticancer …
A novel class of penipanoid C-inspired 2-benzoyl-1-methyl-2, 3-dihydroquinazolin-4 (1H)-
ones (3a-3f) and 1-methyl-2-(3, 4, 5-trihydroxybenzoyl)-2, 3-dihydroquinazolin-4 (1H)-one …
ones (3a-3f) and 1-methyl-2-(3, 4, 5-trihydroxybenzoyl)-2, 3-dihydroquinazolin-4 (1H)-one …
Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells
L Chen, Y Zhang, J Liu, W Wang, X Li, L Zhao… - European Journal of …, 2017 - Elsevier
A series of novel 4-anilinoquinazoline derivatives with (E)-propen-1-yl moiety were
designed, synthesized and evaluated for biological activities inávitro. Most compounds …
designed, synthesized and evaluated for biological activities inávitro. Most compounds …
Development of a series of novel 4-anlinoquinazoline derivatives possessing quinazoline skeleton: Design, synthesis, EGFR kinase inhibitory efficacy, and evaluation …
J Chang, H Ren, M Zhao, Y Chong, W Zhao… - European Journal of …, 2017 - Elsevier
anilinoquinazoline-based derivatives represent an attractive scaffold for small molecular
EGFR-TKIs in the field of medicinal chemistry. A series of novel heterocyclic substituted …
EGFR-TKIs in the field of medicinal chemistry. A series of novel heterocyclic substituted …
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study
Abstract A Ta 2 O 5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer …
New acetamide (IV ae) and 1, 3-thiazolidinone derivatives (VII ae) were designed,
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
Design, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors
ZY Fang, YH Zhang, CH Chen, Q Zheng… - Chemistry & …, 2022 - Wiley Online Library
A series of novel quinazolinone hydrazide derivatives were designed and synthesized as
EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti …
EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti …
Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues
AS El-Azab, AAM Abdel-Aziz… - Journal of Enzyme …, 2017 - Taylor & Francis
A novel series of 2-substituted mercapto-3-(3, 4, 5-trimethoxybenzyl)-4 (3H)-quinazolinones
1–20 was synthesised and evaluated for in vitro antitumour activity. N-(4-Chlorophenyl)-2-[(3 …
1–20 was synthesised and evaluated for in vitro antitumour activity. N-(4-Chlorophenyl)-2-[(3 …
Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity
RM Aly, RAT Serya, AM El-Motwally, A Esmat… - Bioorganic …, 2017 - Elsevier
EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
Synthesis and in vitro antitumor activities of novel 4-anilinoquinazoline derivatives
V Chandregowda, AK Kush, GC Reddy - European journal of medicinal …, 2009 - Elsevier
A series of 6, 7-dialkoxy-4-anilinoquinazolines were designed, synthesized by substituting
different heterocycles on 6-position and a variety of anilines on 4-position of the quinazoline …
different heterocycles on 6-position and a variety of anilines on 4-position of the quinazoline …
Design and Synthesis of some new 2, 4, 6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents
HA Allam, EE Aly, AK Farouk, AM El Kerdawy… - Bioorganic …, 2020 - Elsevier
The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
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