Iron species can participate in the Fenton or Fenton‐like reaction to generate oxidizing
species that can cause oxidative damages to biomolecules and induce oxidative stress in …

Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

Iron plays a crucial role in many physiological processes of the human body, but iron is
continuously deposited in the brain as we age. Early studies found iron overload is directly …

Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …

Alzheimer's disease (AD) is a devastating progressive neurodegenerative disease
characterized by neuronal dysfunction, and decreased memory and cognitive function. Iron …

Reactive oxygen species (ROS) play a key role in the neurodegeneration processes.
Increased oxidative stress damages lipids, proteins, and nucleic acids in brain tissue, and it …

Many evidences indicate that oxidative stress plays a significant role in a variety of human
disease states, including neurodegenerative diseases. Iron is an essential metal for almost …

Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …

In the development of Alzheimer's disease (AD), cell death is common. Novel cell death form—
ferroptosis is discovered in recent years. Ferroptosis is an iron-regulated programmed cell …