A peptide selectively recognizes Gram-negative bacteria and forms a bacterial extracellular trap (BET) through interfacial self-assembly

XL Sha, GT Lv, QH Chen, X Cui, L Wang… - Journal of Materials …, 2024 - pubs.rsc.org
An innate immune system intricately leverages unique mechanisms to inhibit colonization of
external invasive Bacteria, for example human defensin-6, through responsive …

Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity

N Gao, J Wang, C Fang, P Bai, Y Sun, W Wu… - Drug Resistance …, 2023 - Elsevier
The increasing prevalence of multidrug-resistant bacterial infections necessitates the
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …

A biomimetic peptide recognizes and traps bacteria in vivo as human defensin-6

Y Fan, XD Li, PP He, XX Hu, K Zhang, JQ Fan… - Science …, 2020 - science.org
Using broad-spectrum antibiotics for microbial infection may cause flora disequilibrium, drug-
resistance, etc., seriously threatening human health. Here, we design a human defensin-6 …

Surface-Induced Peptide Nanofibers for Selective Bacteria Trapping

T Li, C Zhu, C Liang, T Deng, X Wu, K Wen… - ACS Applied Nano …, 2023 - ACS Publications
The abuse of antibiotics has led to the emergence of various drug-resistant bacterial strains
that threaten human health. Other than a continuous screen for antibiotics, alternative …

Double-edged nanobiotic platform with protean functionality: Leveraging the synergistic antibacterial activity of a food-grade peptide to mitigate multidrug-resistant …

P Kumar, AA Shaikh, P Kumar, VK Gupta… - … Applied Materials & …, 2022 - ACS Publications
While persistent efforts are being made to develop a novel arsenal against bacterial
pathogens, the development of such materials remains a formidable challenge. One such …

Biomaterial‐interrelated bacterial sweeper: simplified self‐assembled octapeptides with double‐layered Trp zipper induces membrane destabilization and bacterial …

Y Fang, Y Zhu, L Li, Z Lai, N Dong, A Shan - Small Methods, 2021 - Wiley Online Library
Abstract Treatment of microbial‐associated infections continues to be hampered by impaired
antibacterial efficiency and the variability in nanomedicines. Herein, an octapeptide library …

[HTML][HTML] Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

L Schnaider, S Brahmachari, NW Schmidt… - Nature …, 2017 - nature.com
Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

Bacteria‐Responsive Self‐Assembly of Antimicrobial Peptide Nanonets for Trap‐and‐Kill of Antibiotic‐Resistant Strains

NDT Tram, J Xu, D Mukherjee… - Advanced Functional …, 2023 - Wiley Online Library
Bacterial trapping using nanonets is a ubiquitous immune defense mechanism against
infectious microbes. These nanonets can entrap microbial cells, effectively arresting their …

Mechanistic Investigation of a Self-Assembling Peptide against Escherichia coli

C Chen, G Li, X Cui, J Chen, Q Yu, C Zong, Y Zhao… - Langmuir, 2020 - ACS Publications
Because of their distinctive mode of action in targeting bacterial cell membranes,
antimicrobial peptides (AMPs) are increasingly regarded as a potential candidate for the …

Coassembled Multicomponent Protein Nanoparticles Elicit Enhanced Antibacterial Activity

CKO Dzuvor, HH Shen, VS Haritos, L He - ACS nano, 2024 - ACS Publications
The waning pipeline of the useful antibacterial arsenal has necessitated the urgent
development of more effective antibacterial strategies with distinct mechanisms to rival the …