Hypothalamic agouti-related peptide (AgRP) and neuropeptide Y-expressing neurons have
a critical role in driving food intake, but also in modulating complex, non-feeding behaviours …

Abstract Agouti-related peptide (AGRP)-expressing neurons are activated by fasting—this
causes hunger,,–, an aversive state that motivates the seeking and consumption of food …

The ability to develop counter-regulatory mechanisms to maintain energy balance in
response to environmental and physiologic insults is essential for survival, but the …

Maintaining energy homeostasis requires coordinating physiology and behavior both on an
acute timescale to adapt to rapid fluctuations in caloric intake and on a chronic timescale to …

Hypothalamic neurons that co-express agouti-related protein (AgRP), neuropeptide Y and γ-
aminobutyric acid (GABA) are known to promote feeding and weight gain by integration of …

Anorexia nervosa (AN) is a debilitating and deadly disease characterized by low body mass
index due to diminished food intake, and oftentimes concurrent hyperactivity. A high …

Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide
(AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus …

Abstract Activation of Agouti-Related Peptide (AgRP)-expressing neurons promotes feeding
and insulin resistance. Here, we examine the contribution of neuropeptide Y (NPY) …

Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide
Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus …

In addition to their role in promoting feeding and obesity development, hypothalamic arcuate
agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be …