In vivo gene silencing by chemically modified and stable siRNA
T Rana - US Patent App. 10/672,069, 2005 - Google Patents
The present invention provides compositions for RNA inter ference and methods of use
thereof. In particular, the inven tion provides small interfering RNAs (siRNAs) having …
thereof. In particular, the inven tion provides small interfering RNAs (siRNAs) having …
Methods and compositions for therapeutic use of RNA interference
M Davis, G Jensen, S Pun - US Patent App. 10/440,506, 2004 - Google Patents
The present invention provides methods and compositions for attenuating expression of a
target gene in Vivo. In general, the method includes administering RNAi constructs (such as …
target gene in Vivo. In general, the method includes administering RNAi constructs (such as …
Methods and compositions for therapeutic use of rna interference
M Davis, G Jensen, S Pun - US Patent App. 10/288,230, 2003 - Google Patents
The present invention provides methods and compositions for attenuating expression of a
target gene in vivO. In general, the method includes administering RNAi constructs (such as …
target gene in vivO. In general, the method includes administering RNAi constructs (such as …
Modified siRNA molecules and uses thereof
I Maclachlan, A Judge - US Patent 8,101,741, 2012 - Google Patents
Targeted silencing of disease-associated genes by Syn thetic siRNA holds considerable
promise as a novel therapeu tic strategy. However, unmodified siRNA can be immuno …
promise as a novel therapeu tic strategy. However, unmodified siRNA can be immuno …
Methods and compositions for enhancing the efficacy and specificity of RNAi
PD Zamore, G Hutvagner, D Schwarz… - US Patent …, 2012 - Google Patents
The present invention provides methods of enhancing the e? icacy and speci? city of RNAi.
The invention also provides compositions for mediating RNAi. In particular, the invention …
The invention also provides compositions for mediating RNAi. In particular, the invention …
High potency siRNAS for reducing the expression of target genes
D Brown, L Ford, R Jarvis, V Pallotta… - US Patent App. 10 …, 2003 - Google Patents
(57) ABSTRACT Correspondence Address: FULBRIGHT & JAWORSKI LLP The present
invention provides improved methods of attenu 600 CONGRESSAVE. ating gene …
invention provides improved methods of attenu 600 CONGRESSAVE. ating gene …
siRNA induced systemic gene silencing in mammalian systems
D Leake, A Reynolds, A Khvorova… - US Patent App. 10 …, 2004 - Google Patents
The present invention is directed to methods and compositions for performing gene
silencing in mammalian cells by targeting a region of a non-protein coding target nucleic …
silencing in mammalian cells by targeting a region of a non-protein coding target nucleic …
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
D Brown, L Ford, R Jarvis - US Patent App. 10/298,480, 2004 - Google Patents
The present invention concerns methods and compositions involving the production or
generation of siRNA mixtures or pools capable of triggering RNA-mediated interference …
generation of siRNA mixtures or pools capable of triggering RNA-mediated interference …
Modified polynucleotides for reducing off-target effects in RNA interference
D Leake, A Reynolds, A Khvorova, W Marshall… - US Patent …, 2009 - Google Patents
Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …
are provided The methods and compositions permit effective and efficient applications of …
Functional and hyperfunctional siRNA directed against Bcl-2
A Khvorova, A Reynolds, D Leake, W Marshall… - US Patent …, 2009 - Google Patents
(74) Attorney, Agent, or Firm Kalow & Springut, LLP: Related US Application Data Scott D.
Locke, Esq.(60) Division of application No. 11/083,784, filed on Mar.(57) ABSTRACT 18 …
Locke, Esq.(60) Division of application No. 11/083,784, filed on Mar.(57) ABSTRACT 18 …