Compulsive drug-taking is associated with habenula–frontal cortex connectivity
As a critical node connecting the forebrain with the midbrain, the lateral habenula (LHb)
processes negative feedback in response to aversive events and plays an essential role in …
processes negative feedback in response to aversive events and plays an essential role in …
From controlled to compulsive drug-taking: The role of the habenula in addiction
V Mathis, PJ Kenny - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Addiction is now recognized as a neurobiological and cognitive brain disorder and is
generally viewed as a switch from recreational or voluntary to compulsive substance use …
generally viewed as a switch from recreational or voluntary to compulsive substance use …
[PDF][PDF] Prefrontal-habenular microstructural impairments in human cocaine and heroin addiction
The habenula (Hb) is central to adaptive reward-and aversion-driven behaviors, comprising
a hub for higher-order processing networks involving the prefrontal cortex (PFC). Despite an …
a hub for higher-order processing networks involving the prefrontal cortex (PFC). Despite an …
[HTML][HTML] A focus on reward prediction and the lateral habenula: functional alterations and the behavioral outcomes induced by drugs of abuse
NM Graziane, PA Neumann, Y Dong - Frontiers in Synaptic …, 2018 - frontiersin.org
The lateral habenula (LHb) regulates reward learning and controls the updating of reward-
related information. Drugs of abuse have the capacity to hijack the cellular and neurocircuit …
related information. Drugs of abuse have the capacity to hijack the cellular and neurocircuit …
[HTML][HTML] Lateral habenula involvement in impulsive cocaine seeking
The lateral habenula (LHb) is a brain structure receiving inputs from limbic forebrain areas
and innervating major midbrain monoaminergic nuclei. Evidence indicates LHb involvement …
and innervating major midbrain monoaminergic nuclei. Evidence indicates LHb involvement …
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula
Addictive substances mediate positive and negative states promoting persistent drug use.
However, substrates for aversive effects of drugs remain elusive. We found that, in mouse …
However, substrates for aversive effects of drugs remain elusive. We found that, in mouse …
[HTML][HTML] Neuronal adaptations in the lateral habenula during drug withdrawal: Preclinical evidence for addiction therapy
The epithalamic lateral habenula (LHb) regulates monoaminergic systems and contributes
to the expression of both appetitive and aversive behaviours. Over the past years, the LHb …
to the expression of both appetitive and aversive behaviours. Over the past years, the LHb …
Orbitofrontal, dorsal striatum, and habenula functional connectivity in psychiatric patients with substance use problems
Substance abuse is commonly defined as the persistence of drug use despite negative
consequences. Recent preclinical work has shown that higher input from the orbitofrontal …
consequences. Recent preclinical work has shown that higher input from the orbitofrontal …
[HTML][HTML] Interaction between dysfunctional connectivity at rest and heroin cues-induced brain responses in male abstinent heroin-dependent individuals
Background The majority of previous heroin cue-reactivity functional magnetic resonance
imaging (fMRI) studies focused on local function impairments, such as inhibitory control …
imaging (fMRI) studies focused on local function impairments, such as inhibitory control …
Medial habenula cholinergic signaling regulates cocaine‐associated relapse‐like behavior
Propensity to relapse, even following long periods of abstinence, is a key feature in
substance use disorders. Relapse and relapse‐like behaviors are known to be induced, in …
substance use disorders. Relapse and relapse‐like behaviors are known to be induced, in …