[PDF][PDF] The chaperone FACT and histone H2B ubiquitination maintain S. pombe genome architecture through genic and subtelomeric functions
M Murawska, T Schauer, A Matsuda, MD Wilson… - Molecular cell, 2020 - cell.com
The histone chaperone FACT and histone H2B ubiquitination (H2Bub) facilitate RNA
polymerase II (Pol II) passage through chromatin, yet it is not clear how they cooperate …
polymerase II (Pol II) passage through chromatin, yet it is not clear how they cooperate …
Acetylation-Dependent Recruitment of the FACT Complex and Its Role in Regulating Pol II Occupancy Genome-Wide in Saccharomyces cerevisiae
Histone chaperones, chromatin remodelers, and histone modifying complexes play a critical
role in alleviating the nucleosomal barrier for DNA-dependent processes. Here, we have …
role in alleviating the nucleosomal barrier for DNA-dependent processes. Here, we have …
FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics
M Nune, MT Morgan, Z Connell, L McCullough… - Elife, 2019 - elifesciences.org
Monoubiquitination of histone H2B (H2B-Ub) plays a role in transcription and DNA
replication, and is required for normal localization of the histone chaperone, FACT. In yeast …
replication, and is required for normal localization of the histone chaperone, FACT. In yeast …
The FACT Histone Chaperone Guides Histone H4 Into Its Nucleosomal Conformation in Saccharomyces cerevisiae
L McCullough, B Poe, Z Connell, H Xin, T Formosa - Genetics, 2013 - academic.oup.com
The pob3-Q308K mutation alters the small subunit of the Saccharomyces cerevisiae
histone/nucleosome chaperone Facilitates Chromatin Transactions (FACT), causing defects …
histone/nucleosome chaperone Facilitates Chromatin Transactions (FACT), causing defects …
Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone
L McCullough, R Rawlins, A Olsen, H Xin… - Genetics, 2011 - academic.oup.com
Abstract FACT (FAcilitates Chromatin Transcription/Transactions) plays a central role in
transcription and replication in eukaryotes by both establishing and overcoming the …
transcription and replication in eukaryotes by both establishing and overcoming the …
[PDF][PDF] FACT is recruited to the+ 1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner
C Jeronimo, A Angel, VQ Nguyen, JM Kim, C Poitras… - Molecular cell, 2021 - cell.com
The histone chaperone FACT occupies transcribed regions where it plays prominent roles in
maintaining chromatin integrity and preserving epigenetic information. How it is targeted to …
maintaining chromatin integrity and preserving epigenetic information. How it is targeted to …
[HTML][HTML] FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation
M Ransom, SK Williams, ML Dechassa, C Das… - Journal of biological …, 2009 - ASBMB
The packaging of the eukaryotic genome into chromatin represses gene expression by
blocking access of the general transcription machinery to the underlying DNA sequences …
blocking access of the general transcription machinery to the underlying DNA sequences …
[HTML][HTML] H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation
A Luo, J Kong, J Chen, X Xiao, J Lan, X Li, C Liu… - Nature …, 2023 - nature.com
Histone H2B mono-ubiquitination at lysine 120 (ubH2B) has been found to regulate
transcriptional elongation by collaborating with the histone chaperone FACT (Facilitates …
transcriptional elongation by collaborating with the histone chaperone FACT (Facilitates …
[PDF][PDF] FACT disrupts nucleosome structure by binding H2A-H2B with conserved peptide motifs
FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that
the H2A-H2B binding activity that is central to FACT function resides in short acidic regions …
the H2A-H2B binding activity that is central to FACT function resides in short acidic regions …
Establishment and maintenance of chromatin architecture are promoted independently of transcription by the histone chaperone FACT and H3-K56 acetylation in …
LL McCullough, TH Pham, TJ Parnell, Z Connell… - Genetics, 2019 - academic.oup.com
Using a combination of in vitro biochemistry, genetics, and genomics, McCullough and
Pham et al. explore how the histone: DNA contact at the entry/exit site of nucleosomes …
Pham et al. explore how the histone: DNA contact at the entry/exit site of nucleosomes …