[HTML][HTML] Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer
MT Rodrigues, APP Michelli, GF Caso, PR de Oliveira… - Pharmaceuticals, 2023 - mdpi.com
Anaplastic thyroid cancer (ATC) is an aggressive form of thyroid cancer (TC), accounting for
50% of total TC-related deaths. Although therapeutic approaches against TC have improved …
50% of total TC-related deaths. Although therapeutic approaches against TC have improved …
Combined effects of baicalein and docetaxel on apoptosis in 8505c anaplastic thyroid cancer cells via downregulation of the ERK and Akt/mTOR pathways
CH Park, SE Han, IS Nam-Goong… - Endocrinology and …, 2018 - synapse.koreamed.org
Background Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies.
Docetaxel, a microtubule stabilizer, is a common chemotherapeutic agent used to treat …
Docetaxel, a microtubule stabilizer, is a common chemotherapeutic agent used to treat …
Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway
Y Hu, Q Wen, Y Cai, Y Liu, W Ma, Q Li, F Song, Y Guo… - Phytomedicine, 2023 - Elsevier
Background Anaplastic thyroid cancer (ATC) is one of the fatal cancers and has not effective
treatments. Alantolactone (ATL), a terpenoid extracted from traditional Chinese medicinal …
treatments. Alantolactone (ATL), a terpenoid extracted from traditional Chinese medicinal …
Combination nitazoxanide and auranofin treatment has synergistic anticancer activity in anaplastic thyroid cancer and act by enhanced activation of multiple cell death …
Purpose: Anaplastic thyroid cancer (ATC) is one of the most aggressive human cancers, with
a median survival time of 6 months and with no current curative treatment. We have used …
a median survival time of 6 months and with no current curative treatment. We have used …
Arctigenin induces necroptosis through mitochondrial dysfunction with CCN1 upregulation in prostate cancer cells under lactic acidosis
YJ Lee, HS Nam, MK Cho, SH Lee - Molecular and Cellular Biochemistry, 2020 - Springer
Arctigenin, a mitochondrial complex I inhibitor, has been identified as a potential anti-tumor
agent, but the involved mechanism still remains elusive. Herein, we studied the underlying …
agent, but the involved mechanism still remains elusive. Herein, we studied the underlying …
Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin
M Garg, D Kanojia, A Mayakonda, TS Ganesan… - Scientific reports, 2017 - nature.com
Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies having no
effective treatment. Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor …
effective treatment. Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor …
Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study
L Wu, X Huang, Y Kuang, Z Xing, X Deng… - Drug design …, 2019 - Taylor & Francis
Objective Thapsigargin (TG) is a natural product that exists in most parts of the plant Thapsia
garganica L. and possesses potential anticancer activities against variety tumor cell lines …
garganica L. and possesses potential anticancer activities against variety tumor cell lines …
[HTML][HTML] Anticancer effects of natural phytochemicals in anaplastic thyroid cancer
Y Li, J Zhang, H Zhou, Z Du - Oncology Reports, 2022 - spandidos-publications.com
Anaplastic thyroid cancer (ATC) is an aggressive and lethal malignancy having a dismal
prognosis. Phytochemicals are bioactive components obtained from plants that have been …
prognosis. Phytochemicals are bioactive components obtained from plants that have been …
Combination of SL327 and Sunitinib Malate leads to an additive anti-cancer effect in doxorubicin resistant thyroid carcinoma cells
W Wang, J Zhou, L Zhao, S Chen - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Abstract Background Receptor tyrosine kinases (RTKs) play crucial roles in numerous
cancer cell processes including cell survival, proliferation, and migration. MEK1/2 MAPK …
cancer cell processes including cell survival, proliferation, and migration. MEK1/2 MAPK …
Additive effect by combination of Akt inhibitor, MK-2206, and PDGFR inhibitor, tyrphostin AG 1296, in suppressing anaplastic thyroid carcinoma cell viability and …
H Che, H Guo, X Si, Q You, W Lou - OncoTargets and therapy, 2014 - Taylor & Francis
The phosphatidylinositol-3-kinase/Akt pathway and receptor tyrosine kinases regulate many
tumorigenesis related cellular processes including cell metabolism, cell survival, cell motility …
tumorigenesis related cellular processes including cell metabolism, cell survival, cell motility …