Abstract Ethnopharmacological relevance Cinobufagin (Huachansu), an aqueous extract
from the dried skin of the toad Bufo bufo gargarizans Cantor (frog skin), is a biologically …

Ethnopharmacological relevance Bufonis (VB), an animal drug called Chansu in China, is
the product of the secretion of Bufo gargarizans Cantor or B. melanostictus Schneider. As a …

Cisplatin (CDDP) has been shown to be a promising anticancer drug that is effective against
many types of cancer, which include osteosarcoma (OS). However, its therapeutic …

Here, we assessed the anti-colorectal cancer (CRC) cell activity of cinobufagin (CBG). We
found that CBG exerted potent cytotoxic and anti-proliferative activity against CRC lines …

Cinobufagin, a major component of cinobufacini (huachansu), is an important cardenolidal
steroid. Several studies have suggested that cinobufagin has potent anti-cancer effects. The …

Colorectal cancer (CRC) has become one of the most common types of cancer with the
highest morbidity and mortality rates globally. Cinobufagin, a natural product extracted from …

Osteosarcoma (OS) is a major cause of cancer-related mortality in children and young adults
worldwide. Due to preexisting or acquired chemoresistance, the current standard …

Cinobufagin (CBG) is a cardiotoxic bufanolide steroid secreted by the skin and parotid
venom glands of the Asiatic toad Bufo bufo gargarizans (called Chan-Su). Although CBG is …

Background/Aims: Osteosarcoma is a common primary malignant bone tumor that mainly
occurs in childhood and adolescence. Despite developments in the diagnosis and treatment …

The cinobufagin (CB) has a broad spectrum of cytotoxicity to inhibit cell proliferation of
various human cancer cell lines, but the molecular mechanisms still remain elusive. Here we …