Mass spectrometric and functional aspects of drug–protein conjugation
The covalent binding of drugs (metabolites) to proteins to form drug–protein adducts can
have an adverse effect on the body. These adducts are thought to be responsible for …
have an adverse effect on the body. These adducts are thought to be responsible for …
Separation and detection methods for covalent drug–protein adducts
S Zhou - Journal of Chromatography B, 2003 - Elsevier
Covalent binding of reactive metabolites of drugs to proteins has been a predominant
hypothesis for the mechanism of toxicity caused by numerous drugs. The development of …
hypothesis for the mechanism of toxicity caused by numerous drugs. The development of …
Drug–protein adducts: past, present, and future
TA Baillie - Medicinal Chemistry Research, 2020 - Springer
Research over the past half-century has demonstrated that the metabolism of drugs and
other foreign compounds to chemically reactive intermediates that bind covalently to …
other foreign compounds to chemically reactive intermediates that bind covalently to …
Mass spectrometry approaches to monitor protein–drug interactions
Recent advances in mass spectrometry-based approaches have enabled the investigation
of drug–protein interactions in various ways including the direct detection of drug–target …
of drug–protein interactions in various ways including the direct detection of drug–target …
Proteomics in immunological reactions to drugs
A Ariza, MI Montañez, D Perez-Sala - Current opinion in allergy …, 2011 - journals.lww.com
Immunological reactions to drugs pose important clinical problems. Since early works
exploring drug–protein interactions, there has been steady progress in this field. However …
exploring drug–protein interactions, there has been steady progress in this field. However …
Drug− protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development
It is generally accepted that there is neither a well-defined nor a consistent link between the
formation of drug− protein adducts and organ toxicity. Because the potential does exist …
formation of drug− protein adducts and organ toxicity. Because the potential does exist …
Identification and quantification of drug–albumin adducts in serum samples from a drug exposure study in mice
L Switzar, LM Kwast, H Lingeman, M Giera… - … of Chromatography B, 2013 - Elsevier
The formation of drug–protein adducts following the bioactivation of drugs to reactive
metabolites has been linked to adverse drug reactions (ADRs) and is a major complication …
metabolites has been linked to adverse drug reactions (ADRs) and is a major complication …
Advances in mass spectrometry-based epitope mapping of protein therapeutics
Monoclonal antibody (mAb) has grown to be the major asset in protein therapeutics market
since its initial introduction in 1980s. To identify a suitable mAb as a drug candidate for …
since its initial introduction in 1980s. To identify a suitable mAb as a drug candidate for …
Revealing promiscuous drug–target interactions by chemical proteomics
The (poly-) pharmacological activities of a drug can only be understood if its interactions with
cellular components are comprehensively characterized. Mass spectrometry-based …
cellular components are comprehensively characterized. Mass spectrometry-based …
Drug bioactivation covalent binding to target proteins and toxicity relevance
A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …