Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's disease
C Picard, N Nilsson, A Labonté, D Auld… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction We examine the role of brain apolipoprotein B (apoB) as a putative marker of
early tau pathology and cognitive decline. Methods Cerebrospinal fluid (CSF) samples from …
early tau pathology and cognitive decline. Methods Cerebrospinal fluid (CSF) samples from …
[HTML][HTML] Plasma p-tau181 level predicts neurodegeneration and progression to Alzheimer's dementia: a longitudinal study
YL Wang, J Chen, ZL Du, H Weng, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Background: Plasma-based biomarkers would be potential biomarkers for early diagnosis of
Alzheimer's disease (AD) because they are more available and cost-effective than …
Alzheimer's disease (AD) because they are more available and cost-effective than …
[HTML][HTML] P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles
KEJ Wesenhagen, BM Tijms, L Boonkamp… - Alzheimer's Research & …, 2022 - Springer
Background We previously identified four Alzheimer's disease (AD) subgroups with
increasingly higher cerebrospinal fluid (CSF) levels of tau phosphorylated at threonine 181 …
increasingly higher cerebrospinal fluid (CSF) levels of tau phosphorylated at threonine 181 …
[HTML][HTML] Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related …
Plasma phosphorylated tau (p-tau) and glial fibrillary acidic protein (GFAP) both reflect early
changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels …
changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels …
[HTML][HTML] Characterization of Alzheimer's tau biomarker discordance using plasma, CSF, and PET
Y Guo, YY Huang, XN Shen, SD Chen, H Hu… - Alzheimer's research & …, 2021 - Springer
Background We aimed to investigate the tau biomarker discrepancies of Alzheimer's
disease (AD) using plasma tau phosphorylated at threonine 181 (p-tau181), cerebrospinal …
disease (AD) using plasma tau phosphorylated at threonine 181 (p-tau181), cerebrospinal …
Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease
KY Tzen, SY Yang, TF Chen, TW Cheng… - ACS chemical …, 2014 - ACS Publications
Recent advances in biomarkers provide the possibility of early or preclinical diagnosis of
Alzheimer's pathology. Currently, decreased levels of Aβ-42 and increased levels of tau …
Alzheimer's pathology. Currently, decreased levels of Aβ-42 and increased levels of tau …
Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease
Blood‐based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific
for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were …
for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were …
Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's …
AM Fagan, MA Mintun, AR Shah, P Aldea… - EMBO molecular …, 2009 - embopress.org
Alzheimer's disease (AD) pathology is estimated to develop many years before detectable
cognitive decline. Fluid and imaging biomarkers may identify people in early symptomatic …
cognitive decline. Fluid and imaging biomarkers may identify people in early symptomatic …
[HTML][HTML] Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change
DS Smirnov, NJ Ashton, K Blennow, H Zetterberg… - Acta …, 2022 - Springer
Plasma biomarkers related to amyloid, tau, and neurodegeneration (ATN) show great
promise for identifying these pathological features of Alzheimer's Disease (AD) as shown by …
promise for identifying these pathological features of Alzheimer's Disease (AD) as shown by …
Association of serum apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer's pathology
H Hu, L Tan, YL Bi, W Xu, L Tan… - Annals of Clinical …, 2020 - Wiley Online Library
Objective To examine whether apolipoprotein B (ApoB), apolipoprotein A‐1 (ApoA1), or their
ratio (ApoB/A1) were associated with early changes in cerebrospinal fluid (CSF) biomarkers …
ratio (ApoB/A1) were associated with early changes in cerebrospinal fluid (CSF) biomarkers …
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