Poor aqueous solubility is one of the key reasons for slow dissolution rate and poor
intestinal absorption and finally that causes low therapeutic efficacy of many existing drugs …

Polyoxyethanyl-α-tocopheryl sebacate (PTS) is an amphiphilic compound with self-
emulsifying properties known to form micelles. In this work, we report the production of PTS …

Being a BCS class II drug and a good substrate for microsomal enzymes, tamoxifen (TAM)
offers a scope for research owing to poor aqueous solubility and compromised …

Purpose Methotrexate (MTX), a potent anticancer drug, shows low oral bioavailability due to
its low aqueous solubility and permeability. Moreover, its multidrug resistance (MDR) in …

The aim of this study was to prepare and characterize a new nanocarrier for oral delivery of
tamoxifen citrate (TMC) as a lipophilic oral administrated drug. This drug has low oral …

Several samples of polymeric micelles, formed by amphiphilic derivatives of PHEA, obtained
by grafting into polymeric backbone of PEGs and/or hexadecylamine groups (PHEA‐PEG …

Chitosan is a widely employed polysaccharide with positive zeta-potential and better
tissue/cell adhesion. Its hydrophilicity, high viscosity, and insolubility at physiological pH are …

Tamoxifen (TAM) is frequently prescribed for the management breast cancer, but is
associated with the challenges like compromised aqueous solubility and poor bioavailability …

Highly water-soluble prodrug micelle (50-fold compared with free MTX) of methotrexate-
polyethyleneglycol-rhodamine (MTX-PEG-rhodamine) and MTX-mPEG was synthesized by …

The present work aims to develop tamoxifen-loaded polymeric micelles and explore their
potential in topical delivery of the drug to breast cancer cells. The PLGA–PEG copolymer …