The positional cloning of the gene responsible for cystic fibrosis (CF) was the important first
step in understanding the basic defect and pathophysiology of the disease. This study aims …

The spectrum of cystic fibrosis (CF) mutations was determined in 105 patients by using
denaturing gradiert gel electrophoresis to screen the entire coding regiors and adjacent …

Genetics is the branch of biology concerned with study of individual genes and how they
work whereas genomics is involved with the analysis of all genes and their interactions. Both …

Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene. The disease is characterized …

Over the past decade, nearly 1,000 variants have been identified in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene in classic and atypical cystic fibrosis …

Purpose: To develop a sequencing assay for the CFTR gene to identify mutations in patients
with cystic fibrosis (CF). Methods: An automated assay format was developed to sequence …

Cystic fibrosis (CF) is a complicated disease involving many organ systems. Identification of
the cystic fibrosis transmembrane regulator (CFTR) genetic code has not only enhanced our …

The identification of the cystic fibrosis transmembrane conductance regulator gene (CFTR)
in 1989 represents a landmark accomplishment in human genetics. Since that time, there …

Patients with cystic fibrosis (CF) manifest a multisystemic disease due to mutations in the
gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR); despite …

We have conducted a comprehensive study of the molecular basis of cystic fibrosis (CF) in
350 German CF patients. A screening approach based on single-strand conformation …