Role of estrogen in women's Alzheimer's disease risk as modified by APOE
AC Valencia‐Olvera… - Journal of …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is characterized by numerous sexual dimorphisms that impact the
development, progression, and probably the strategies to prevent and treat the most …
development, progression, and probably the strategies to prevent and treat the most …
Female sex and Alzheimer's risk: the menopause connection
O Scheyer, A Rahman, H Hristov, C Berkowitz… - The journal of …, 2018 - Springer
Along with advanced age and apolipoprotein E (APOE)-4 genotype, female sex is a major
risk factor for developing late-onset Alzheimer's disease (AD). Considering that AD …
risk factor for developing late-onset Alzheimer's disease (AD). Considering that AD …
Estrogen and Alzheimer's disease: the apolipoprotein connection
NJ MacLusky - Endocrinology, 2004 - academic.oup.com
The contribution of estrogens to the prevention of neurodegenerative disorders has attracted
considerable attention over the last few years as a result of conflicting data from clinical …
considerable attention over the last few years as a result of conflicting data from clinical …
APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice
J Kunzler, KL Youmans, C Yu, MJ LaDu, LM Tai - Neuroscience letters, 2014 - Elsevier
The post-menopausal loss of estrogen is key in the increased incidence of Alzheimer's
disease (AD) in women. However, estrogen therapy (ET) clinical trials have produced …
disease (AD) in women. However, estrogen therapy (ET) clinical trials have produced …
[HTML][HTML] Sex and gender driven modifiers of Alzheimer's: the role for estrogenic control across age, race, medical, and lifestyle risks
A Rahman, H Jackson, H Hristov… - Frontiers in aging …, 2019 - frontiersin.org
Research indicates that after advanced age, the major risk factor for late-onset Alzheimer's
disease is female sex. Out of every three AD patients, two are females with postmenopausal …
disease is female sex. Out of every three AD patients, two are females with postmenopausal …
Age, APOE and sex: triad of risk of Alzheimer's disease
Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
[HTML][HTML] Estrogens still represent an attractive therapeutic approach for Alzheimer's disease
E Tamagno, M Guglielmotto - Neural Regeneration Research, 2022 - journals.lww.com
Alzheimer's disease (AD) is a progressive neurodegenerative condition that goes from mild
cognitive impairment in prodromal disease to severely disabling deficits in advanced stages …
cognitive impairment in prodromal disease to severely disabling deficits in advanced stages …
[HTML][HTML] Increased Alzheimer's risk during the menopause transition: a 3-year longitudinal brain imaging study
Two thirds of all persons with late-onset Alzheimer's disease (AD) are women. Identification
of sex-based molecular mechanisms underpinning the female-based prevalence of AD …
of sex-based molecular mechanisms underpinning the female-based prevalence of AD …
[HTML][HTML] Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European …
Background The risk of dementia is higher in women than men. The metabolic
consequences of estrogen decline during menopause accelerate neuropathology in …
consequences of estrogen decline during menopause accelerate neuropathology in …
Women and Alzheimer's disease
AJ Lerner - The Journal of Clinical Endocrinology & Metabolism, 1999 - academic.oup.com
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with
aging. It can also be classified as a complex polygenetic disease, such as hypertension …
aging. It can also be classified as a complex polygenetic disease, such as hypertension …