Aims Epicardium and epicardium-derived cells are critical players in myocardial fibrosis.
Mesenchymal stem cell–derived extracellular vesicles (EVs) have been studied for cardiac …

Abstract Background Extracellular vesicles (EVs) derived from various cell sources exert
cardioprotective effects during cardiac ischemic injury. Our previous study confirmed that …

Although cardiosphere-derived cells (CDCs) improve cardiac function and outcomes in
patients with single ventricle physiology, little is known about their safety and therapeutic …

Cardiac fibrosis is a hallmark in late-stage familial dilated cardiomyopathy (DCM) patients,
although the underlying mechanism remains elusive. Cardiac exosomes (Exos) have been …

Cardiac hypertrophy is a common pathological change accompanied by various
cardiovascular diseases; however, its underlying mechanisms remain elusive. Mounting …

The adult mammalian heart lacks the ability to sufficiently regenerate itself, leading to the
progressive deterioration of function and heart failure after ischemic injuries such as …

Ischemic cardiomyopathy is treated mainly with thrombolytic drugs, percutaneous coronary
intervention, and coronary artery bypass grafting to recanalize blocked vessels. Myocardial …

Cell therapy has received significant attention as a therapeutic approach to restore cardiac
function after myocardial infarction. Accumulating evidence supports that beneficial effects …

Aims After a myocardial infarction, the adult human heart lacks sufficient regenerative
capacity to restore lost tissue, leading to heart failure progression. Finding novel ways to …

The purpose of the present study was to define the role of mesenchymal stem cell (MSC)–
derived extracellular vesicles (EVs) in the progression of myocardial infarction (MI)–induced …