[HTML][HTML] Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy

P Sarantis, E Koustas… - World journal of …, 2020 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases, with an
average 5-year survival rate of less than 10%. Unfortunately, the majority of patients have …

Immunotherapy and pancreatic cancer: unique challenges and potential opportunities

K Young, DJ Hughes… - … advances in medical …, 2018 - journals.sagepub.com
Despite decades of research, pancreatic ductal adenocarcinoma (PDAC) continues to have
the worst 5-year survival of any malignancy. With 338,000 new cases diagnosed and over …

Advances in immunotherapeutics in pancreatic ductal adenocarcinoma

T Chouari, FS La Costa, N Merali, MD Jessel… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is the most common type of
pancreatic cancer, responsible for the majority of cases and ranking seventh as a leading …

Pancreatic cancer and immunotherapy: a clinical overview

FEF Timmer, B Geboers, S Nieuwenhuizen, M Dijkstra… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a
dismal prognosis. While immunotherapy has been deemed a breakthrough treatment for …

Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma

J Fan, MF Wang, HL Chen, D Shang, JK Das, J Song - Molecular cancer, 2020 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is an incurable cancer resistant to traditional
treatments, although a limited number of early-stage patients can undergo radical resection …

Immunologic Strategies in Pancreatic Cancer: Making Cold Tumors Hot

NA Ullman, PR Burchard, RF Dunne… - Journal of Clinical …, 2022 - ascopubs.org
The rising incidence and persistent dismal 5-year overall survival of pancreatic ductal
adenocarcinoma (PDAC) highlight the need for new effective systemic therapies …

Pancreatic ductal adenocarcinoma: a strong imbalance of good and bad immunological cops in the tumor microenvironment

ED Foucher, C Ghigo, S Chouaib, J Galon… - Frontiers in …, 2018 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers
with very few available treatments. For many decades, gemcitabine was the only treatment …

Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects

KY Li, JL Yuan, D Trafton, JX Wang, N Niu… - Chronic diseases and …, 2020 - mednexus.org
The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-
immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular …

[HTML][HTML] Immunotherapy in pancreatic ductal adenocarcinoma: an emerging entity?

IH Sahin, G Askan, ZI Hu, EM O'Reilly - Annals of Oncology, 2017 - Elsevier
The genomic-plasticity of the immune system creates a broad immune repertoire engaged to
tackle cancer cells. Promising clinical activity has been observed with several immune …

Broadening the impact of immunotherapy to pancreatic cancer: challenges and opportunities

VP Balachandran, GL Beatty, SK Dougan - Gastroenterology, 2019 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest
cancer in the United States by 2025, with 5-year survival at less than 10%. In other …