Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies
M Moradi, A Mousavi, Z Emamgholipour… - European Journal of …, 2023 - Elsevier
Angiogenesis, the formation of new blood vessels from the existing vasculature, is pivotal in
the migration, growth, and differentiation of endothelial cells in normal physiological …
the migration, growth, and differentiation of endothelial cells in normal physiological …
Design, synthesis, in vitro antiproliferative evaluation and in silico studies of new VEGFR-2 inhibitors based on 4-piperazinylquinolin-2 (1H)-one scaffold
Angiogenesis is essential in the growth of solid tumors which need oxygen and nutrients
supply to grow in size. The VEGF/VEGFR-2 signaling pathway plays an important role in …
supply to grow in size. The VEGF/VEGFR-2 signaling pathway plays an important role in …
Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[g]quinazoline Derivatives (In Vitro)
HA Abuelizz, M Marzouk, AH Bakheit, HM Awad… - Molecules, 2020 - mdpi.com
A series of 3-ethyl (methyl)-2-thioxo-2, 3-dihydrobenzo [g] quinazolines (1–17) were
synthesized, characterized, and evaluated in vitro for their antiangiogenesis VEGFR-2 …
synthesized, characterized, and evaluated in vitro for their antiangiogenesis VEGFR-2 …
Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors
In our attempt to discover effective anticancer agents, three series of novel quinazoline-
based compounds have been designed, synthesized and tested as VEGFR-2 inhibitors. Five …
based compounds have been designed, synthesized and tested as VEGFR-2 inhibitors. Five …
Discovery of new VEGFR-2 inhibitors: design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies
EB Elkaeed, RG Yousef, MM Khalifa, A Ibrahim… - Molecules, 2022 - mdpi.com
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: Design, synthesis, antiproliferative, docking and MD simulation studies
A new set of quinoline and isatine derivatives were synthesized as antiangiogenic VEGFR-2
inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit …
inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit …
Discovery of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors: Design, synthesis, and anti-proliferative evaluation
IH Eissa, AGA El-Helby, HA Mahdy, MM Khalifa… - Bioorganic …, 2020 - Elsevier
Sixteen novel quinazoline-based derivatives were designed and synthesized via
modification of the VEGFR-2 reported inhibitor 7 in order to increase the binding affinity of …
modification of the VEGFR-2 reported inhibitor 7 in order to increase the binding affinity of …
Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma
A series of new VEGFR-2 inhibitors were designed, synthesized and evaluated for their anti-
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
Design, synthesis and molecular modeling of new quinazolin-4 (3H)-one based VEGFR-2 kinase inhibitors for potential anticancer evaluation
AE Abdallah, SI Eissa, MMS Al Ward, RR Mabrouk… - Bioorganic …, 2021 - Elsevier
Globally cancer is the second leading cause of death. So that this work is an attempt to
develop new effective anti-cancer agents. In line with pharmacophoric features of VEGFR-2 …
develop new effective anti-cancer agents. In line with pharmacophoric features of VEGFR-2 …
Fragment-based investigation of thiourea derivatives as VEGFR-2 inhibitors: a cross-validated approach of ligand-based and structure-based molecular modeling …
S Banerjee, S Kejriwal, B Ghosh, G Lanka… - Journal of …, 2024 - Taylor & Francis
Angiogenesis is mediated by the vascular endothelial growth factor (VEGF) that plays a key
role in the modulation of progression, invasion and metastasis, related to solid tumors and …
role in the modulation of progression, invasion and metastasis, related to solid tumors and …