Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …
Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation
N Li, BJJM Brundel - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …
affects millions of people worldwide. AF is associated with common risk factors, including …
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
Inflammation, inflammasome activation, and atrial fibrillation: evidence for causation and new therapeutic targets
DR Van Wagoner, MK Chung - Circulation, 2018 - Am Heart Assoc
Markers of inflammation have been linked to atrial fibrillation (AF), but whether inflammation
is causal or merely a marker of increased risk has long been debated. The association …
is causal or merely a marker of increased risk has long been debated. The association …
The crosstalk between cardiomyocyte calcium and inflammasome signaling pathways in atrial fibrillation
Atrial fibrillation (AF) is the most frequent arrhythmia in adults. The prevalence and incidence
of AF is going to increase substantially over the next few decades. Because AF increases …
of AF is going to increase substantially over the next few decades. Because AF increases …
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
[HTML][HTML] Inflammation, atrial fibrillation, and the potential role for colchicine therapy
B Varghese, DI Feldman, C Chew, E Valilis… - Heart Rhythm O2, 2021 - Elsevier
Increasing evidence suggests that the “NACHT-LRR and PYD domain-containing protein
3”(NLRP3) inflammasome plays an important role in atherosclerotic cardiovascular disease …
3”(NLRP3) inflammasome plays an important role in atherosclerotic cardiovascular disease …
[HTML][HTML] Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation: mechanisms and potential therapeutic implications
Inflammasomes are high molecular weight protein complexes in the cytosol of immune and
other cells that play a critical role in the innate immune system in response to cellular stress …
other cells that play a critical role in the innate immune system in response to cellular stress …
Role of inflammation in atrial fibrillation pathophysiology and management
M Harada, DR Van Wagoner, S Nattel - Circulation journal, 2015 - jstage.jst.go.jp
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia, but the methods
available for treating AF and its complications (of which the most important is …
available for treating AF and its complications (of which the most important is …
NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias
Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with
enhanced inflammatory response. However, whether inflammatory signaling is causally …
enhanced inflammatory response. However, whether inflammatory signaling is causally …