Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway

J Zhou, Y Jiang, H Chen, Y Wu, L Zhang - Cell proliferation, 2020 - Wiley Online Library
Abstract Objectives Tanshinone I (Tan‐I) is one of the vital fatsoluble monomer components,
which extracted from Chinese medicinal herb Salvia miltiorrhiza Bunge. It has been shown …

Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells

IT Nizamutdinova, GW Lee… - International …, 2008 - spandidos-publications.com
Abstract Danshen (Salvia miltiorrhiza Bunge) is a herb that has been widely and
successfully used for treating inflammatory diseases in clinics in Asia. The relatively …

Tanshinone IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM‐5 leukemia cells

SM Yun, JH Jung, SJ Jeong, EJ Sohn… - Phytotherapy …, 2014 - Wiley Online Library
Although tanshinone IIA (Tan IIA) from Salviae miltiorrhizae was known to induce apoptosis
in various cancers, its underlying mechanism of autophagic cell death was not reported yet …

Tanshinone IIA acts via p38 MAPK to induce apoptosis and the down-regulation of ERCC1 and lung-resistance protein in cisplatin-resistant ovarian cancer cells

JW Jiao, F Wen - Oncology reports, 2011 - spandidos-publications.com
Tanshinone IIA is known to induce apoptosis in several types of cancer cells. However, little
is known about its activity in chemoresistant cells. The aim of this study was to investigate …

The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG

C Lv, HW Zeng, JX Wang, X Yuan, C Zhang… - Cell Death & …, 2018 - nature.com
Abstract Tanshinone IIA (Tan IIA), the primary bioactive compound derived from the
traditional Chinese medicine (TCM) Salvia miltiorrhiza Bunge, has been reported to possess …

[HTML][HTML] Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells

SL Yuan, YQ Wei, XJ Wang, F Xiao, SF Li… - World Journal of …, 2004 - ncbi.nlm.nih.gov
AIM: To evaluate the effects of tanshinone II-A on inducing growth inhibition and apoptosis of
human hepatocellular carcinoma (HCC) cells. METHODS: The human hepatocellular …

Tanshinone IIA: New perspective on the anti-tumor mechanism of A traditional natural medicine

W Zhang, C Liu, J Li, Y Lu, H Li, J Zhuang… - The American journal …, 2022 - World Scientific
The search for natural and efficacious antineoplastic drugs, with minimal toxicity and side
effects, is an important part of antitumor drug research and development. Tanshinone IIA is …

Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane …

TL Chiu, CC Su - International journal of molecular …, 2010 - spandidos-publications.com
Abstract Tanshinone IIA (Tan-IIA) is extracted from Danshen and known to inhibit
proliferation and induce apoptosis in many cancer cells. We aimed to elucidate its …

Tanshinone IIA inhibits glucose metabolism leading to apoptosis in cervical cancer

Z Liu, W Zhu, X Kong, X Chen, X Sun… - Oncology …, 2019 - spandidos-publications.com
Cancer requires aerobic glycolysis to supply the energy required for proliferation. Existing
evidence has revealed that blocking glycolysis results in apoptosis of cancer cells …

The anticancer properties of tanshinones and the pharmacological effects of their active ingredients

L Fu, B Han, Y Zhou, J Ren, W Cao, G Patel… - Frontiers in …, 2020 - frontiersin.org
Cancer is a common malignant disease worldwide with an increasing mortality in recent
years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the …