Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing

T Kempf, A Zarbock, D Vestweber… - Journal of molecular …, 2012 - Springer
The wound healing response after myocardial infarction (MI) involves a cascade of
molecular and cellular events that lead to a replacement of the necrotic area with a collagen …

Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Targeting inflammatory pathways in myocardial infarction

P Christia, NG Frangogiannis - European journal of clinical …, 2013 - Wiley Online Library
Acute cardiomyocyte necrosis in the infarcted heart generates damage‐associated
molecular patterns (DAMP s), activating complement and T oll‐L ike R eceptor …

Targeted pharmacotherapy for ischemia reperfusion injury in acute myocardial infarction

A Rout, US Tantry, M Novakovic, A Sukhi… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Achieving reperfusion immediately after acute myocardial infarction improves
outcomes; despite this, patients remain at a high risk for mortality and morbidity at least for …

Pathophysiology of ST-segment elevation myocardial infarction: novel mechanisms and treatments

F Montecucco, F Carbone… - European heart …, 2016 - academic.oup.com
Despite major advances in mechanical and pharmacological reperfusion strategies to
improve acute myocardial infarction (MI) injury, substantial mortality, morbidity, and …

Inflammatory mechanisms in myocardial infarction

G Ren, O Dewald… - Current Drug Targets …, 2003 - ingentaconnect.com
Myocardial infarction is associated with an inflammatory response, ultimately leading to
healing and scar formation. Reperfused myocardial infarcts exhibit an enhanced …

Pathophysiology of myocardial infarction and acute management strategies

M Tibaut, D Mekis, D Petrovic - … & Hematological Agents in …, 2016 - ingentaconnect.com
On an annual basis, 13.2% of all deaths are attributable to coronary artery disease (CAD),
which makes CAD-with 7.4 million deaths–the leading cause of death in the world. In this …

An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives

L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality?

DM Yellon, GF Baxter - Heart, 2000 - heart.bmj.com
Acute coronary occlusion is the leading cause of morbidity and mortality in the Western
world, and according to the World Health Organisation will be the major cause of death in …