Interest in the endothelium has been growing in recent decades and the traditional belief
that it provides an inert interface between blood and the vessel wall is no longer the case. It …

The endothelium is a thin monocellular layer lining the entire human vascular system,
separating blood from interstitium. It plays a core role in the vascular tone by releasing a …

The endothelium is the main regulator of vascular wall homeostasis. Physiologically,
endothelial cells maintain a relaxed vascular tone and low levels of oxidative stress, in part …

Recent research on endothelial dysfunction supports its clinical significance in hypertension,
and has led to important insights into the pathophysiology of the disease. These …

In 1980, Furchgott and Zawadzki demonstrated that the ability of a blood vessel to relax to
acetylcholine is entirely dependent upon the presence of an intact endothelium b1. This …

Endothelial dysfunction is a characteristic aspect of most of the conditions associated with
atherosclerosis and is commonly found as an early feature in atherothrombotic vascular …

A large body of evidence indicates that patients with essential hypertension, and even more
those with complicated hypertension, are characterized by endothelial dysfunction …

An enormous number of studies in the last two decades have been devoted to investigating
the role of the endothelium in cardiovascular diseases. Nonetheless, the optimal …

Endothelial dysfunction is a common feature of hypertension, and it results from the
imbalanced release of endothelium-derived relaxing factors (EDRFs; in particular, nitric …

Endothelium can deeply influence vascular tone and structure. The main endothelium-
derived factor is nitric oxide (NO), which not only is a potent vasodilator but also inhibits …