Background Neuropathic pain is associated with significant co-morbidity, including anxiety
and depression, which impact considerably on the overall patient experience. However …

Background Behavioral criteria that confirm neuropathic pain in animal injury models are
undefined. Therefore, the authors sought clinically relevant measures that distinguish pain …

BACKGROUND: Patients with chronic pain frequently suffer affective disorders, particularly
anxiety and depression. Although clinical research on the relationship between pain and …

Although many types of nerve damage can cause neuropathic pain, there are substantial
commonalities in neuropathic pain symptoms, and patients can be divided into sub-groups …

Introduction The induction of neuropathic pain-like behaviors in rodents often requires
surgical intervention. This engages acute nociceptive signaling events that contribute to pain …

Background Although inflammation induces pain, immune cells also produce mediators that
can effectively counteract it. To further elucidate the role of the immune response, we …

Chronic neuropathic pain, resulting from damage to the central or peripheral nervous
system, is a prevalent and debilitating condition, affecting 7-18% of the population1, 2 …

Background Chronic pain is often accompanied by comorbidities like anxiety and
depression. The temporal correlations, as well as the underlying mechanisms of these …

Back-translating the clinical manifestations of human disease burden into animal models is
increasingly recognized as an important facet of preclinical drug discovery. We …

Background Chronic pain and depression are two complex states with sensory/somatic and
emotional components, and they may mutually exacerbate one another in conditions of …