[HTML][HTML] ERK5 signalling in prostate cancer promotes an invasive phenotype
AK Ramsay, SRC McCracken, M Soofi… - British journal of …, 2011 - nature.com
Background: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)–extracellular
signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a …
signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a …
Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer
Abnormal intracellular signaling contributes to carcinogenesis and may represent novel
therapeutic targets. mitogen/extracellular signal-regulated kinase kinase-5 (MEK5) …
therapeutic targets. mitogen/extracellular signal-regulated kinase kinase-5 (MEK5) …
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion
PB Mehta, BL Jenkins, L McCarthy, L Thilak… - Oncogene, 2003 - nature.com
The novel mitogen/extracellular-signal-regulated kinase kinase 5/extracellular signal-
regulated kinase-5 (MEK5/ERK5) pathway has been implicated in the regulation of cellular …
regulated kinase-5 (MEK5/ERK5) pathway has been implicated in the regulation of cellular …
[HTML][HTML] Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer
I Ahmad, LB Singh, ZH Yang, G Kalna, J Fleming… - British journal of …, 2013 - nature.com
Background: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)–extracellular
signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a …
signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a …
ERK5 and its role in tumour development
PA Lochhead, R Gilley, SJ Cook - Biochemical Society …, 2012 - portlandpress.com
The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated
kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has …
kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has …
[HTML][HTML] Clinical significance and regulation of ERK5 expression and function in cancer
M Monti, J Celli, F Missale, F Cersosimo, M Russo… - Cancers, 2022 - mdpi.com
Simple Summary Alterations of the MEK5/ERK5 signaling pathway have been described in
several tumors, and emerging data are trying to explain the complexity of ERK5-related …
several tumors, and emerging data are trying to explain the complexity of ERK5-related …
Constitutive activation of MAPK/ERK inhibits prostate cancer cell proliferation through upregulation of BRCA2 corrigendum in/10.3892/ijo. 2016.3487
L Moro, AA Arbini, E Marra… - … journal of oncology, 2007 - spandidos-publications.com
BRCA2 is central to an utterly diverse biological behavior elicited after integrin-mediated
normal and prostate cancer cell adhesion to basement membrane (BM) and extracellular …
normal and prostate cancer cell adhesion to basement membrane (BM) and extracellular …
The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target
AES Simoes, CMP Rodrigues, PM Borralho - Drug discovery today, 2016 - Elsevier
Highlights•The present review highlights the emerging clinical relevance of MEK5/ERK5
signalling as a therapeutic target and prognostic factor in several top-leading diagnosed …
signalling as a therapeutic target and prognostic factor in several top-leading diagnosed …
[HTML][HTML] Impact of ERK5 on the Hallmarks of Cancer
Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …
MAP kinases and prostate cancer
G Rodríguez-Berriguete, B Fraile… - Journal of signal …, 2012 - Wiley Online Library
The three major mitogen‐activated protein kinases (MAPKs) p38, JNK, and ERK are signal
transducers involved in a broad range of cell functions including survival, apoptosis, and cell …
transducers involved in a broad range of cell functions including survival, apoptosis, and cell …