The impact of epitranscriptomics on antiviral innate immunity

B Mersinoglu, S Cristinelli, A Ciuffi - Viruses, 2022 - mdpi.com
Epitranscriptomics, ie, chemical modifications of RNA molecules, has proven to be a new
layer of modulation and regulation of protein expression, asking for the revisiting of some …

The emerging role of RNA modifications in the regulation of antiviral innate immunity

J Tong, W Zhang, Y Chen, Q Yuan, NN Qin… - Frontiers in …, 2022 - frontiersin.org
Posttranscriptional modifications have been implicated in regulation of nearly all biological
aspects of cellular RNAs, from stability, translation, splicing, nuclear export to localization …

Post-transcriptional regulation of viral protein expression and function

S Zuñiga, JA Corcoran - Frontiers in Virology, 2023 - frontiersin.org
Post-transcriptional regulation includes both RNA and protein modifications, leading to the
modulation of protein expression levels or protein functions. These modifications may …

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

DR Ribeiro, A Nunes, D Ribeiro, AR Soares - Frontiers in Genetics, 2023 - frontiersin.org
Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during
viral infections. By modulating the modification landscape of viral and host RNAs, viruses …

Viral epitranscriptomics

EM Kennedy, DG Courtney, K Tsai… - Journal of virology, 2017 - Am Soc Microbiol
Although it has been known for over 40 years that eukaryotic mRNAs bear internal base
modifications, it is only in the last 5 years that the importance of these modifications has …

The epitranscriptome and innate immunity

MA O'Connell, NM Mannion, LP Keegan - PLoS genetics, 2015 - journals.plos.org
Our knowledge of the variety and abundances of RNA base modifications is rapidly
increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA …

[HTML][HTML] Proteomic analysis of antiviral innate immunity

JD Albarnaz, MP Weekes - Current Opinion in Virology, 2023 - Elsevier
Highlights•Antiviral innate immunity is regulated by changes in cellular proteins.•These
include changes in abundance, localisation, interaction and PTMs.•Viral immune evasion …

Regulation of antiviral innate immunity by chemical modification of viral RNA

N Li, TM Rana - Wiley Interdisciplinary Reviews: RNA, 2022 - Wiley Online Library
More than 100 chemical modifications of RNA, termed the epitranscriptome, have been
described, most of which occur in prokaryotic and eukaryotic ribosomal, transfer, and …

Transcriptomics and quantitative proteomics in virology

A Berard, AL Kroeker, KM Coombs - Future Virology, 2012 - Taylor & Francis
Viral proteins and their roles in virus replication are typically well understood. However, their
interactions with host proteins are currently not as well defined, and a better understanding …

Making the mark: the role of adenosine modifications in the life cycle of RNA viruses

SR Gonzales-van Horn, P Sarnow - Cell host & microbe, 2017 - cell.com
Viral epitranscriptomics is a newly emerging field that has identified unique roles for RNA
modifications in modulating life cycles of RNA viruses. Despite the observation of a handful …