[HTML][HTML] Defining high-fat-diet rat models: metabolic and molecular effects of different fat types
R Buettner, KG Parhofer… - Journal of …, 2006 - jme.bioscientifica.com
Abstract High-fat (HF)-diet rodent models have contributed significantly to the analysis of the
pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly …
pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly …
[HTML][HTML] Reduced fat mass in rats fed a high oleic acid–rich safflower oil diet is associated with changes in expression of hepatic PPARα and adipose SREBP-1c …
SC Hsu, C Huang - The Journal of nutrition, 2006 - Elsevier
PPARs and sterol regulatory element-binding protein-1c (SREPB-1c) are fatty acid–
regulated transcription factors that control lipid metabolism at the level of gene expression …
regulated transcription factors that control lipid metabolism at the level of gene expression …
[HTML][HTML] Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
N Turner, GM Kowalski, SJ Leslie, S Risis, C Yang… - Diabetologia, 2013 - Springer
Aims/hypothesis While it is well known that diet-induced obesity causes insulin resistance,
the precise mechanisms underpinning the initiation of insulin resistance are unclear. To …
the precise mechanisms underpinning the initiation of insulin resistance are unclear. To …
[HTML][HTML] Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice
Aims/hypothesis Complex changes in gene expression are associated with insulin
resistance and non-alcoholic fatty liver disease (NAFLD) promoted by feeding a high-fat diet …
resistance and non-alcoholic fatty liver disease (NAFLD) promoted by feeding a high-fat diet …
High‐fat diets: modeling the metabolic disorders of human obesity in rodents
R Buettner, J Schölmerich, LC Bollheimer - Obesity, 2007 - Wiley Online Library
Abstract Research Methods and Procedures: High‐fat (HF) diet feeding can induce obesity
and metabolic disorders in rodents that resemble the human metabolic syndrome. However …
and metabolic disorders in rodents that resemble the human metabolic syndrome. However …
[HTML][HTML] Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets
BD Pachikian, A Essaghir, JB Demoulin, AM Neyrinck… - PloS one, 2011 - journals.plos.org
Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6
polyunsaturated fatty acid (PUFA) ratio in hepatic phospholipids. The metabolic …
polyunsaturated fatty acid (PUFA) ratio in hepatic phospholipids. The metabolic …
[HTML][HTML] Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding
MK Montgomery, NL Hallahan, SH Brown, M Liu… - Diabetologia, 2013 - Springer
Aims/hypothesis Metabolic disorders are commonly investigated using knockout and
transgenic mouse models. A variety of mouse strains have been used for this purpose …
transgenic mouse models. A variety of mouse strains have been used for this purpose …
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
Leptin-deficient ob/ob mice show many characteristics of obesity, including excess
peripheral adiposity as well as severe hepatic steatosis, at least in part, due to increased …
peripheral adiposity as well as severe hepatic steatosis, at least in part, due to increased …
Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues
Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) limit abdominal fat depot hypertrophy.
This could be due to regulation of the expression of proteins involved in adipose tissue …
This could be due to regulation of the expression of proteins involved in adipose tissue …
Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue
N Saravanan, A Haseeb… - European Journal of …, 2005 - academic.oup.com
Abstract Objective Trans-fatty acids (TFAs) are formed during partial hydrogenation of
vegetable oils and are shown to be more atherogenic than saturated fatty acids (SFAs). Our …
vegetable oils and are shown to be more atherogenic than saturated fatty acids (SFAs). Our …