Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …

Amino acids play central roles in cancer progression beyond their function as building
blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been …

The antitumour enzyme L-asparaginase (L-asparagine amidohydrolase, EC 3.5. 1.1,
ASNase), which catalyses the deamidation of L-asparagine (Asn) to L-aspartic acid and …

Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors.
Asparagine is an amino acid that is synthesized by normal cells. However, some cancer …

Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to
asparagine and glutamate in an ATP-dependent reaction. The enzyme is ubiquitous in its …

Abstract l-Asparaginase (l-ASP), a bacterial enzyme used since the 1970s to treat acute
lymphoblastic leukemia, selectively starves cells that cannot synthesize sufficient …

Modern clinical treatments of childhood acute lymphoblastic leukemia (ALL) employ enzyme-
based methods for depletion of blood asparagine in combination with standard …

We and others have reported that the anticancer activity of l-asparaginase (ASNase) against
asparagine synthetase (ASNS)-positive cell types requires ASNase glutaminase activity …

Complete amino acid deprivation in mammalian cells causes a significant enhancement in
gene expression for a number of important cellular activities; among these is asparagine …