Simple Summary Cancer cells often present a different set of proteins on their surface than
normal cells. This also applies to integrins, a class of 24 cell surface receptors which mainly …

Accurate and rapid detection of rapidly growing and metastatic tumors is of great importance
for implementation of a tailored therapeutic regimen. A number of imaging procedures are …

Background In the context of nuclear medicine and theranostics, integrin-related research
and development was, for most of the time, focused predominantly on'RGD peptides' and the …

Purpose Molecular imaging of α v β 3 integrin has exhibited real potential to guide the
appropriate use of anti-angiogenic therapies. However, an incomplete understanding of the …

“RGD” is frequently pictured as a ligand for αvβ3-integrin and useful for molecular targeting
of angiogenesis—which is about as simplistic as the idea that laser beams are green or red …

Integrins are a family of proteins that facilitate cellular adhesion to and migration on the
extracellular matrix proteins found in intercellular spaces and basement membranes …

Introduction: The expression of alpha-five beta-three (αVβ3) integrins is upregulated in
various malignancies undergoing angiogenesis. The development of integrin antagonists as …

Imaging of angiogenic processes is of great interest in preclinical research as well as in
clinical settings. The most commonly addressed target structure for imaging angiogenesis is …

Non-invasive investigation of integrin expression is an interesting approach in nuclear
medicine department. Indeed, integrins are overexpressed in a wide array of diseases …

Introduction The α v β 3 integrin, which is expressed by angiogenic epithelium and some
tumor cells, is an attractive target for the development of both imaging agents and …