Glioblastoma is a rapidly progressing tumor quite resistant to conventional treatment. These
features are currently assigned to a self-sustaining population of glioblastoma stem cells …

Tumor cells with stem cell properties are considered to play major roles in promoting the
development and malignant behavior of aggressive cancers. Therapeutic strategies that …

Gliomas are the most prevailing intracranial tumors, which account for approximately 36% of
the primary brain tumors of glial cells. Glioblastoma multiforme (GBM) possesses a higher …

This review discusses recent studies on dendrimer-based nanoparticles in cancer
chemotherapy and gene therapy. In order to achieve the high efficacy and low side effects of …

Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to
current treatment options. Despite major advancements in the fields of surgery and …

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor and
is characterized by high mortality and morbidity rates and unpredictable clinical behavior …

While reshaping their microenvironment, tumors are also capable of influencing systemic
processes including myeloid cell production. Therefore, the tumor-induced myeloid cells …

Glioblastoma Multiforme (GBM) is one of the most aggressive forms of all cancers. The
median survival with current standard-of-care radiation and chemotherapy is about 14 …

Background: Cancer is a leading cause of mortality. A vast number of conventional
chemotherapeutic agents are being used to treat cancer; however, these conventional …

This study was aimed to develop and evaluate the TMZ-PAMAM-siRNA [temozolomide-
polyamidoamine dendimer-siRNA] dendriplexes for the effective treatment of glioblastoma …