Retinoic acid protects against lipopolysaccharide-induced ferroptotic liver injury and iron disorders by regulating Nrf2/HO-1 and RARβ signaling

X Lai, A Wu, Y Bing, Y Liu, J Luo, H Yan… - Free Radical Biology …, 2023 - Elsevier
Acute liver injury (ALI) can progress to severe liver diseases, making its prevention and
treatment a focus of research. Retinoic acid (RA) has been shown to have anti-oxidative and …

ATRA regulates innate immunity in liver ischemia/reperfusion injury via RARα/Akt/Foxo1 signaling

C Zhong, L Pu, M Fang, J Rao, X Wang - Biological and …, 2018 - jstage.jst.go.jp
All-trans retinoic acid (ATRA) has been proved to protect liver from ischemia/reperfusion (IR)
injury, however, its mechanism is still unclear. This study is to investigate the mechanism of …

Nrf2‐Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute‐on‐Chronic Liver Failure

J Wu, R Xue, M Wu, X Yin, B Xie… - Oxidative Medicine and …, 2022 - Wiley Online Library
Although massive hepatocyte cell death and oxidative stress constitute major events of
acute‐on‐chronic liver failure (ACLF), the relationship of ferroptosis with ACLF has yet to be …

All-trans retinoic acid alleviates hepatic ischemia/reperfusion injury by enhancing manganese superoxide dismutase in rats

J Rao, C Zhang, P Wang, L Lu… - Biological and …, 2010 - jstage.jst.go.jp
All-trans retinoic acid (atRA) is an active metabolite of vitamin A with antioxidant effects.
There have been few reports on the effects of atRA on liver ischemia/reperfusion (I/R) injury …

[HTML][HTML] Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

J Tschuck, L Theilacker, I Rothenaigner… - Nature …, 2023 - nature.com
Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid
peroxidation. Recent research has identified many regulators that induce or inhibit …

Augmenter of liver regeneration protects the kidney from ischaemia‐reperfusion injury in ferroptosis

L Huang, X Liao, H Sun, X Jiang, Q Liu… - Journal of Cellular and …, 2019 - Wiley Online Library
Acute kidney injury (AKI) is a common and severe clinical condition with high morbidity and
mortality. Ischaemia‐reperfusion (I/R) injury remains the major cause of AKI in the clinic …

Ferulic acid protects against gamma-radiation induced liver injury via regulating JAK/STAT/Nrf2 pathways

RA Gawish, EM Samy, MM Aziz - Archives of Biochemistry and Biophysics, 2024 - Elsevier
This study aims to evaluate the effect and underlying mechanism of ferulic acid (FA) in
alleviating the acute liver injury by ionizing radiation (IR) in vivo. Rats were divided into …

Suppressive effects of retinoids on iron-induced oxidative stress in the liver

H Tsuchiya, Y Akechi, R Ikeda, R Nishio, T Sakabe… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: We previously reported that impaired retinoid signaling in the liver
causes steatohepatitis and hepatocellular carcinoma. Recently, oxidative stress induced by …

[HTML][HTML] Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis

H Wang, C Jiang, Y Yang, J Li, Y Wang, C Wang… - PeerJ, 2022 - peerj.com
This study is intended to explore the protective effects of resveratrol (RES) on iron overload-
induced liver fibrosis and its mechanism. Iron dextran (50 mg/kg) was injected …

[HTML][HTML] All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis

Y Sun, Y He, J Tong, D Liu, H Zhang, T He, Y Bi - Genes & Diseases, 2022 - Elsevier
All-trans retinoic acid (ATRA) can reverse the malignant behaviors of hepatocellular
carcinoma (HCC) cells, thereby exerting anti-HCC effect; however, the underlying …