DNA damage responses (DDR) encompass DNA repair and signal transduction pathways
that effect cell cycle checkpoint arrest and/or apoptosis. How DDR pathways respond to low …

Damage induced in the DNA after exposure of cells to ionizing radiation activates
checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and …

The DNA damage response pathways involve processes of double-strand break (DSB)
repair and cell cycle checkpoint control to prevent or limit entry into S phase or mitosis in the …

In response to diverse genotoxic stresses, cells activate DNA damage checkpoint pathways
to protect genomic integrity and promote survival of the organism. Depending on DNA …

The DNA damage response (DDR) represents a complex network of multiple signaling
pathways involving cell cycle checkpoints, DNA repair, transcriptional programs, and …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

In response to genotoxic stress, which can be caused by environmental or endogenous
genotoxic insults such as ionizing or ultraviolet radiation, various chemicals and reactive …

Cell cycle checkpoints were initially presumed to function as a regulator of cell cycle
machinery in response to different genotoxic stresses, and later found to play an important …

Double-strand breaks (DSBs) are the most detrimental form of DNA damage. Failure to
repair these cytotoxic lesions can result in genome rearrangements conducive to the …

In response to genomic insults cells trigger a signal transduction pathway, known as DNA
damage checkpoint, whose role is to help the cell to cope with the damage by coordinating …