Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent
and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and …

Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It
is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic …

Hyperinsulinism is the single most common mechanism of hypoglycemia in neonates.
Dysregulated insulin secretion is responsible for the transient and prolonged forms of …

Congenital hyperinsulinism (HI) is an inappropriate insulin secretion by the pancreatic β-
cells secondary to various genetic disorders. The incidence is estimated at 1/50, 000 live …

The diagnosis and treatment of congenital hyperinsulinism (CHI) have made a remarkable
progress over the past 20 years and, currently, it is relatively rare to see patients who are left …

BACKGROUND/PURPOSE: Congenital hyperinsulinism (HI) causes severe hypoglycemia
in neonates and infants. Recessive mutations of the beta-cell KATP channel genes cause …

Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in
infants and children. Delays in diagnosis and initiation of appropriate treatment contribute to …

BACKGROUND: Congenital hyperinsunlinism (CHI) is characterized by profound
hypoglycaemia caused by inappropriate insulin secretion. CHI is a heterogeneous disorder …

Hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in children, which if
unrecognized may lead to development delays and permanent neurologicdamage. Prompt …

Objective. To evaluate the neurologic outcomes of neonates and infants suffering from
persistent hyperinsulinemic hypoglycemia of infancy (PHHI). Methods. The neurologic …