Gastroesophageal reflux disease (GERD) is associated with an incompetent lower
esophageal sphincter (LES), resulting in the reflux of gastric contents into the esophagus …

Most pregnant women have symptoms of gastroesophageal reflux disease (GERD) during
pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The …

The lower esophageal sphincter (LES) plays an important role in coordinated esophageal
motility. The present study aimed to elucidate how trypsin affects LES contractility. Porcine …

Introduction Gastro-oesophageal reflux disease (GORD) is characterised by symptoms
(most commonly heartburn) caused by exposure of the oesophageal mucosa to gastric …

Background. Prostaglandins inhibit the contraction of gastrointestinal smooth muscle and
may decrease lower esophageal sphincter tone. The purpose of this study was to determine …

Duodenal reflux of fluids containing trypsin relates to refractory gastroesophageal reflux
disease (GERD). Esophageal peristalsis and clearance are important factors in GERD …

Abstract Prostaglandin E 2 (PGE 2) plays a role in the pathogenesis of gastro-esophageal
reflux disease (GERD). There are 4 subtypes of PGE 2, PGE 2 receptor 1, 2, 3 and 4 (EP 1 …

Background: Transient lower esophageal sphincter relaxation (TLESR) is the major cause of
gastroesophageal reflux disease (GERD). TLESRs are considered to be triggered by …

Objective: Intraluminal acid evokes reflex contraction of oesophageal longitudinal smooth
muscle (LSM) and consequent oesophageal shortening. This reflex may play a role in the …

Esophageal injury from acid exposure related to gastroesophageal reflux disease is a
common problem and a risk factor for development of Barrett's esophagus and esophageal …